Understanding the Chemical Properties of 1-Bromo-3,4,5-trimethoxybenzene
1-Bromo-3,4,5-trimethoxybenzene (CAS: 2675-79-8) is a compound valued for its specific physical and chemical characteristics, which dictate its utility as an intermediate in various industrial applications. A thorough understanding of these properties is vital for chemists and engineers to effectively utilize this compound in synthesis, product development, and quality control.
Physically, 1-Bromo-3,4,5-trimethoxybenzene typically appears as an off-white crystalline powder. This solid form is convenient for handling, storage, and precise weighing in laboratory and industrial settings. Its melting point, generally reported in the range of 78-82 °C, indicates a stable solid state at room temperature. The density of the compound is approximately 1.4 to 1.5 g/cm³, which is a common characteristic for brominated organic compounds of this molecular weight.
Chemically, the compound's molecular formula is C9H11BrO3, with a molecular weight of 247.09 g/mol. The presence of a bromine atom on the aromatic ring makes it susceptible to various nucleophilic substitution and coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. These reactions are foundational for creating carbon-carbon bonds, essential for building complex organic molecules. The three methoxy groups (-OCH3) attached to the benzene ring influence the electronic properties of the molecule, affecting its reactivity and solubility. It is generally insoluble in water but soluble in common organic solvents like ethanol, methanol, and dichloromethane.
Key physical parameters like boiling point, typically around 262-273 °C at standard pressure, and flash point (around 103.7 °C) provide important safety information for handling and processing. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. ensure that the compound maintains a high purity, usually ≥98.0%, which is crucial for its predictable performance in sensitive chemical transformations.
By understanding these physical and chemical properties, researchers and manufacturers can optimize reaction conditions, ensure safe handling practices, and achieve the desired outcomes when using 1-Bromo-3,4,5-trimethoxybenzene in their work. This detailed knowledge underpins its continued importance as a versatile chemical intermediate.
Physically, 1-Bromo-3,4,5-trimethoxybenzene typically appears as an off-white crystalline powder. This solid form is convenient for handling, storage, and precise weighing in laboratory and industrial settings. Its melting point, generally reported in the range of 78-82 °C, indicates a stable solid state at room temperature. The density of the compound is approximately 1.4 to 1.5 g/cm³, which is a common characteristic for brominated organic compounds of this molecular weight.
Chemically, the compound's molecular formula is C9H11BrO3, with a molecular weight of 247.09 g/mol. The presence of a bromine atom on the aromatic ring makes it susceptible to various nucleophilic substitution and coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. These reactions are foundational for creating carbon-carbon bonds, essential for building complex organic molecules. The three methoxy groups (-OCH3) attached to the benzene ring influence the electronic properties of the molecule, affecting its reactivity and solubility. It is generally insoluble in water but soluble in common organic solvents like ethanol, methanol, and dichloromethane.
Key physical parameters like boiling point, typically around 262-273 °C at standard pressure, and flash point (around 103.7 °C) provide important safety information for handling and processing. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. ensure that the compound maintains a high purity, usually ≥98.0%, which is crucial for its predictable performance in sensitive chemical transformations.
By understanding these physical and chemical properties, researchers and manufacturers can optimize reaction conditions, ensure safe handling practices, and achieve the desired outcomes when using 1-Bromo-3,4,5-trimethoxybenzene in their work. This detailed knowledge underpins its continued importance as a versatile chemical intermediate.
Perspectives & Insights
Nano Explorer 01
“5 g/cm³, which is a common characteristic for brominated organic compounds of this molecular weight.”
Data Catalyst One
“Chemically, the compound's molecular formula is C9H11BrO3, with a molecular weight of 247.”
Chem Thinker Labs
“The presence of a bromine atom on the aromatic ring makes it susceptible to various nucleophilic substitution and coupling reactions, such as Suzuki, Heck, and Sonogashira couplings.”