Understanding the Chemical Properties of 2-Bromo-5-nitrothiophene (CAS 13195-50-1)
For chemists and researchers working with organic compounds, a thorough understanding of their chemical properties is foundational to successful synthesis and application. 2-Bromo-5-nitrothiophene (CAS 13195-50-1) is a heterocycle that presents an interesting interplay of functional groups, dictating its reactivity and physical characteristics. NINGBO INNO PHARMCHEM CO.,LTD. provides this essential thiophene derivative and insights into its nature.
Physically, 2-Bromo-5-nitrothiophene is typically observed as a yellow solid. Its melting point generally falls within the range of 44-48°C, a characteristic that confirms its solid state at standard room temperatures. This property is important for handling, storage, and certain reaction conditions where precise temperature control is necessary. As a solid, it is also easier to weigh and transfer accurately in laboratory settings.
The chemical structure of 2-Bromo-5-nitrothiophene is key to its utility. It consists of a five-membered thiophene ring, substituted with a bromine atom at the 2-position and a nitro group at the 5-position. The bromine atom is a good leaving group, making it highly susceptible to nucleophilic substitution and, more importantly, various transition-metal-catalyzed cross-coupling reactions. This includes reactions like Suzuki, Stille, Heck, and Sonogashira couplings, which are indispensable tools for forming new carbon-carbon bonds and constructing complex organic molecules.
The nitro group (-NO2) is a strong electron-withdrawing group. Its presence on the thiophene ring significantly influences the electron density distribution. This electron-withdrawing effect can activate certain positions on the ring for nucleophilic attack or deactivate others for electrophilic substitution. Moreover, the nitro group itself can be chemically transformed, most commonly through reduction to an amino group (-NH2). This transformation opens up a vast array of further synthetic possibilities, such as amide formation, Schiff base condensation, or diazotization reactions.
For those looking to buy 2-Bromo-5-nitrothiophene, understanding these properties is crucial for planning synthetic routes and ensuring optimal reaction conditions. The interplay between the bromine and nitro groups makes this compound a versatile intermediate for synthesizing a wide range of fine chemicals, including those used in pharmaceuticals, agrochemicals, and materials science.
NINGBO INNO PHARMCHEM CO.,LTD. ensures that our 2-Bromo-5-nitrothiophene is produced to high purity standards, typically 97-98%, which is vital for predictable reactivity and successful outcomes in complex syntheses. Our commitment as a manufacturer in China means we focus on delivering consistent quality. Whether for routine laboratory use or advanced research projects, understanding the chemical properties of 2-Bromo-5-nitrothiophene is key to unlocking its full synthetic potential.
Physically, 2-Bromo-5-nitrothiophene is typically observed as a yellow solid. Its melting point generally falls within the range of 44-48°C, a characteristic that confirms its solid state at standard room temperatures. This property is important for handling, storage, and certain reaction conditions where precise temperature control is necessary. As a solid, it is also easier to weigh and transfer accurately in laboratory settings.
The chemical structure of 2-Bromo-5-nitrothiophene is key to its utility. It consists of a five-membered thiophene ring, substituted with a bromine atom at the 2-position and a nitro group at the 5-position. The bromine atom is a good leaving group, making it highly susceptible to nucleophilic substitution and, more importantly, various transition-metal-catalyzed cross-coupling reactions. This includes reactions like Suzuki, Stille, Heck, and Sonogashira couplings, which are indispensable tools for forming new carbon-carbon bonds and constructing complex organic molecules.
The nitro group (-NO2) is a strong electron-withdrawing group. Its presence on the thiophene ring significantly influences the electron density distribution. This electron-withdrawing effect can activate certain positions on the ring for nucleophilic attack or deactivate others for electrophilic substitution. Moreover, the nitro group itself can be chemically transformed, most commonly through reduction to an amino group (-NH2). This transformation opens up a vast array of further synthetic possibilities, such as amide formation, Schiff base condensation, or diazotization reactions.
For those looking to buy 2-Bromo-5-nitrothiophene, understanding these properties is crucial for planning synthetic routes and ensuring optimal reaction conditions. The interplay between the bromine and nitro groups makes this compound a versatile intermediate for synthesizing a wide range of fine chemicals, including those used in pharmaceuticals, agrochemicals, and materials science.
NINGBO INNO PHARMCHEM CO.,LTD. ensures that our 2-Bromo-5-nitrothiophene is produced to high purity standards, typically 97-98%, which is vital for predictable reactivity and successful outcomes in complex syntheses. Our commitment as a manufacturer in China means we focus on delivering consistent quality. Whether for routine laboratory use or advanced research projects, understanding the chemical properties of 2-Bromo-5-nitrothiophene is key to unlocking its full synthetic potential.
Perspectives & Insights
Nano Explorer 01
“This includes reactions like Suzuki, Stille, Heck, and Sonogashira couplings, which are indispensable tools for forming new carbon-carbon bonds and constructing complex organic molecules.”
Data Catalyst One
“Its presence on the thiophene ring significantly influences the electron density distribution.”
Chem Thinker Labs
“This electron-withdrawing effect can activate certain positions on the ring for nucleophilic attack or deactivate others for electrophilic substitution.”