Isoquinoline, a fundamental organic compound identified by CAS number 119-65-3, is a critical intermediate that powers innovation across diverse chemical industries. This heterocyclic aromatic molecule, an isomer of quinoline, features a benzene ring fused with a pyridine ring, granting it unique chemical properties and a wide spectrum of applications. For professionals in R&D, procurement, and manufacturing, a thorough understanding of Isoquinoline is essential.

Chemically, Isoquinoline is a weak base with a pKb of approximately 8.6, similar to pyridine. It typically appears as a white to slightly yellow solidified mass or fragments. Key physical properties include a melting point in the range of 24-28°C and a boiling point of 242°C. Its solubility profile indicates it is practically insoluble in water but readily dissolves in common organic solvents like ethanol and ether. This solubility characteristic makes it adaptable for various reaction conditions and purification processes.

The production of Isoquinoline historically involved isolation from coal tar. Modern synthesis methods, however, offer more controlled and efficient routes. The Pomeranz–Fritsch reaction, utilizing benzaldehyde and aminoacetoaldehyde diethyl acetal under acidic conditions, is a prominent method for its preparation. Other variations and related reactions, such as the Bischler–Napieralski reaction, are also employed for synthesizing Isoquinoline derivatives. Manufacturers continuously refine these processes to ensure high purity and yield.

The utility of Isoquinoline spans several key sectors. In pharmaceuticals, it is a crucial building block for synthesizing active pharmaceutical ingredients (APIs), including those used in cancer therapy (e.g., topoisomerase I inhibitors) and cardiovascular treatments. Its structural backbone is also found in many naturally occurring alkaloids with significant biological activity. For researchers and drug developers, securing a reliable supply of high-purity Isoquinoline is paramount for advancing new therapeutic agents.

Beyond pharmaceuticals, Isoquinoline is integral to the production of dyes and agrochemicals. It serves as an intermediate in creating specific colorants for textiles and industrial applications, and it is used in the synthesis of insecticides and fungicides for crop protection. These applications highlight Isoquinoline's broad impact on consumer goods and agriculture.

For procurement managers and scientists looking to buy Isoquinoline, sourcing from reputable manufacturers is key. When seeking a supplier, consider factors such as purity levels (often 98% or higher), production capacity, and consistency of supply. Manufacturers in China are prominent global suppliers, offering competitive pricing and efficient logistics. Evaluating a supplier's quality certifications, technical support, and adherence to international trade standards is vital for a successful procurement strategy.

In essence, Isoquinoline (CAS 119-65-3) is a foundational chemical intermediate whose properties and applications make it indispensable in modern industry. Understanding its characteristics, production methods, and sourcing considerations empowers businesses to make informed decisions and secure the high-quality materials needed for innovation and manufacturing excellence.