Understanding Methyl Acetoacetate: Key Properties and Chemical Behavior
For any chemical intermediate to be effectively utilized, a thorough understanding of its properties is essential. Methyl Acetoacetate (CAS 105-45-3) is no exception. This colorless, transparent liquid with a distinctive fruity odor possesses a unique set of chemical characteristics that make it invaluable across various industries, from pharmaceuticals to flavors and industrial coatings. NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer in China, ensures our Methyl Acetoacetate meets precise specifications.
One of the most critical aspects of Methyl Acetoacetate is its reactivity, stemming from the presence of the beta-keto ester group. The methylene group situated between the two carbonyls is particularly acidic due to resonance stabilization of the resultant carbanion. This feature allows Methyl Acetoacetate to undergo facile alkylation, acylation, and condensation reactions, including the renowned Claisen condensation and Michael addition. These reactions are fundamental in building more complex organic molecules.
In terms of physical properties, Methyl Acetoacetate typically has a density slightly greater than water and a boiling point around 169-170 °C. Its solubility in water is moderate, about 460 g/L at 20 °C, and it is miscible with many organic solvents. This solubility profile is advantageous for its use in various reaction media and formulations. The CAS 105-45-3 chemical properties dictate its handling and storage requirements, generally involving keeping it in a cool, dry place away from ignition sources due to its flammability.
The stability of Methyl Acetoacetate is another key consideration. While stable under normal storage conditions, it can hydrolyze in the presence of strong acids or bases, particularly at elevated temperatures, reverting to methanol and acetoacetic acid (which further decomposes). This reactivity is often exploited in specific synthetic strategies but must be managed during storage and processing.
When discussing methyl acetoacetate chemical properties, its role in the Biginelli reaction is frequently highlighted. This one-pot, three-component reaction is a cornerstone for synthesizing dihydropyrimidinones, a class of compounds with significant pharmaceutical interest. The reliable supply of high-purity Methyl Acetoacetate from a trusted supplier in China like NINGBO INNO PHARMCHEM CO.,LTD. is essential for the success of such synthetic endeavors.
Whether you are looking to buy Methyl Acetoacetate for pharmaceutical synthesis, flavor creation, or industrial applications, understanding its fundamental chemical behavior is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing detailed technical information and high-quality products to support your chemical needs.
One of the most critical aspects of Methyl Acetoacetate is its reactivity, stemming from the presence of the beta-keto ester group. The methylene group situated between the two carbonyls is particularly acidic due to resonance stabilization of the resultant carbanion. This feature allows Methyl Acetoacetate to undergo facile alkylation, acylation, and condensation reactions, including the renowned Claisen condensation and Michael addition. These reactions are fundamental in building more complex organic molecules.
In terms of physical properties, Methyl Acetoacetate typically has a density slightly greater than water and a boiling point around 169-170 °C. Its solubility in water is moderate, about 460 g/L at 20 °C, and it is miscible with many organic solvents. This solubility profile is advantageous for its use in various reaction media and formulations. The CAS 105-45-3 chemical properties dictate its handling and storage requirements, generally involving keeping it in a cool, dry place away from ignition sources due to its flammability.
The stability of Methyl Acetoacetate is another key consideration. While stable under normal storage conditions, it can hydrolyze in the presence of strong acids or bases, particularly at elevated temperatures, reverting to methanol and acetoacetic acid (which further decomposes). This reactivity is often exploited in specific synthetic strategies but must be managed during storage and processing.
When discussing methyl acetoacetate chemical properties, its role in the Biginelli reaction is frequently highlighted. This one-pot, three-component reaction is a cornerstone for synthesizing dihydropyrimidinones, a class of compounds with significant pharmaceutical interest. The reliable supply of high-purity Methyl Acetoacetate from a trusted supplier in China like NINGBO INNO PHARMCHEM CO.,LTD. is essential for the success of such synthetic endeavors.
Whether you are looking to buy Methyl Acetoacetate for pharmaceutical synthesis, flavor creation, or industrial applications, understanding its fundamental chemical behavior is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing detailed technical information and high-quality products to support your chemical needs.
Perspectives & Insights
Future Origin 2025
“This solubility profile is advantageous for its use in various reaction media and formulations.”
Core Analyst 01
“The CAS 105-45-3 chemical properties dictate its handling and storage requirements, generally involving keeping it in a cool, dry place away from ignition sources due to its flammability.”
Silicon Seeker One
“While stable under normal storage conditions, it can hydrolyze in the presence of strong acids or bases, particularly at elevated temperatures, reverting to methanol and acetoacetic acid (which further decomposes).”