In the realm of advanced materials and chemical synthesis, certain compounds stand out for their unique properties and broad applicability. N-Acryloxysuccinimide (NAS), identified by its CAS number 38862-24-7, is one such crucial chemical intermediate. As a reputable manufacturer and supplier, we are dedicated to providing high-quality NAS that empowers researchers and industries to push the boundaries of innovation.

N-Acryloxysuccinimide is a white powder, typically available in high purities of 98% or 99%. Its molecular structure is a fascinating fusion: it combines a polymerizable acrylamide moiety with a reactive succinimide ester group. This dual functionality is the cornerstone of its utility. The acrylamide group allows NAS to readily participate in various polymerization reactions, such as radical polymerization and RAFT polymerization. This controlled polymerization capability is essential for creating polymers with precisely defined molecular weights, architectures, and properties, making it a sought-after product for chemical manufacturers aiming for advanced polymer development.

On the other hand, the succinimide ester portion of N-Acryloxysuccinimide is designed to react with primary amines. This characteristic makes it an excellent choice for bioconjugation – the process of covalently linking biomolecules like proteins, peptides, or antibodies to synthetic polymers or surfaces. This application is particularly vital in the development of targeted drug delivery systems, diagnostic tools, and functionalized biomaterials. For instance, researchers often buy NAS to create antibody-drug conjugates (ADCs) or to modify surfaces for improved biocompatibility and specific binding capabilities.

The synthesis of N-Acryloxysuccinimide typically involves a multi-step process, often starting from succinic anhydride and acrylamide, followed by dehydration and cyclization. Advanced methods may also utilize decarboxylative cyclization for enhanced efficiency and yield. As a dedicated supplier, we ensure that our manufacturing processes adhere to stringent quality control standards, guaranteeing the purity and consistency of NAS for our customers, whether they are looking to buy for research or industrial-scale production.

Compared to similar compounds like N-Hydroxysuccinimide (NHS) or N-Chlorosuccinimide (NCS), N-Acryloxysuccinimide offers distinct advantages. Its acrylamide group provides better hydrolytic stability than the ester linkage in NHS, making it more robust in aqueous environments. Unlike NCS, which is often used for oxidation or chlorination, NAS’s primary role is in polymerization and bioconjugation, highlighting its specialized applications. These comparative benefits make sourcing NAS from a reliable manufacturer like us a strategic decision for those working in polymer chemistry, bioconjugation, and material science.

In summary, N-Acryloxysuccinimide is a versatile and valuable chemical intermediate. Its ability to participate in controlled polymerization and facilitate amine conjugation makes it indispensable for creating advanced materials, functionalized biomolecules, and innovative nanostructures. We invite you to purchase N-Acryloxysuccinimide from our company to experience its exceptional quality and performance firsthand, and to benefit from our expertise as a leading chemical supplier.