For chemists and formulators engaged in advanced organic synthesis, a thorough understanding of key intermediates is essential for successful product development. N-ethyl-4-pyridinemethanamine (CAS 33403-97-3) is a compound of significant interest due to its versatile chemical structure and applications. This article provides an overview of its properties, potential synthesis pathways, and its importance as a fine chemical intermediate.

N-ethyl-4-pyridinemethanamine, represented by the molecular formula C8H12N2 and a molecular weight of approximately 136.19 g/mol, is characterized by a pyridine ring substituted at the 4-position with an ethylaminomethyl group. This structure imparts specific chemical reactivity, making it suitable for a range of synthetic transformations. Its physical appearance is typically described as a colorless to yellow liquid, with a boiling point of 219.1 °C at 760 mmHg and a flash point of 98.3 °C. Its miscibility with water is also a noteworthy property for handling and formulation.

The synthesis of N-ethyl-4-pyridinemethanamine can be approached through several routes, commonly involving the functionalization of pyridine precursors. One possible method could include the reductive amination of 4-pyridinecarboxaldehyde with ethylamine, or the alkylation of 4-aminomethylpyridine with an ethylating agent. Manufacturers often employ optimized processes to achieve high yields and purity, ensuring the product meets the stringent requirements for its use as a pharmaceutical intermediate or a reagent in specialty chemical production.

Researchers looking to buy N-ethyl-4-pyridinemethanamine are often seeking a reliable building block for constructing more complex molecular architectures. The pyridine nitrogen offers sites for quaternization or coordination, while the secondary amine can undergo a variety of reactions. These characteristics make it a valuable component in the synthesis of biologically active compounds, catalysts, or functional materials.

When considering its procurement, understanding the typical purity levels offered by suppliers is crucial. Many manufacturers, especially those based in China, offer this chemical with purities of 97% or higher, often verified by GC analysis. If you are involved in research that requires specific isotopic labeling or highly pure derivatives, custom synthesis services from specialized chemical companies may be an option.

For professionals aiming to purchase N-ethyl-4-pyridinemethanamine, detailed product specifications, safety data, and reliable supply chain management are key considerations. Engaging with established chemical suppliers who can provide comprehensive technical support and consistent product quality ensures that your synthetic projects can proceed smoothly and efficiently.