1-Phenyl-1-cyclopentanecarbonitrile (CAS 77-57-6) is a compound that chemists value for its specific properties and predictable reactivity. As a key organic synthesis raw material, its physical and chemical characteristics dictate its suitability for various applications, particularly in the pharmaceutical and fine chemical sectors. Understanding these attributes is essential for effective utilization in synthesis and for ensuring safe handling and storage.

Physically, 1-Phenyl-1-cyclopentanecarbonitrile typically presents as a clear liquid, often described as colorless to pale yellow. Its density is around 1.03 g/cm³, and it possesses a refractive index ranging from 1.5325 to 1.5345. Importantly, its boiling point is noted as 135-140 °C at 10 mmHg, indicating a degree of thermal stability under reduced pressure. The flash point of 113.5°C suggests it is moderately combustible, requiring appropriate safety precautions during handling and storage. Its solubility in water is low, but it readily dissolves in common organic solvents, a crucial trait for facilitating reactions in solution.

Chemically, the compound's reactivity is largely centered around the nitrile group (-CN) and the benzylic position. The nitrile group is a versatile functional handle that can be hydrolyzed to a carboxylic acid or reduced to a primary amine. These transformations are fundamental in organic synthesis, enabling the introduction of nitrogen or oxygen-containing functionalities into target molecules. The phenyl group influences the electron density of the ring and provides a site for electrophilic aromatic substitution reactions, although the cyclopentane ring might undergo other transformations preferentially. As a pharmaceutical development building block, these reactive sites allow chemists to construct complex drug molecules efficiently.

For researchers and manufacturers, sourcing high-purity 1-Phenyl-1-cyclopentanecarbonitrile from a reliable supplier like NINGBO INNO PHARMCHEM CO.,LTD. is crucial. The specified purity of ≥98.0% ensures that the compound's inherent reactivity can be leveraged without interference from unwanted byproducts. Whether you are a seasoned chemist or a procurement specialist, understanding these properties will guide your decision-making process for optimizing your synthetic strategies and ensuring the success of your projects. We pride ourselves on being a dependable supplier of quality chemical intermediates.