Trifluoroacetic Anhydride (TFAA), with the CAS number 407-25-0, is a potent and highly reactive chemical intermediate widely used in organic synthesis. As a clear, colorless liquid with a characteristic odor, it is indispensable for many complex chemical transformations. NINGBO INNO PHARMCHEM CO.,LTD., a dedicated manufacturer and supplier, provides this vital reagent and emphasizes the importance of understanding its properties and safe handling procedures.

Key Properties of Trifluoroacetic Anhydride:

  • Chemical Formula: C4F6O3
  • Molar Mass: 210.03 g/mol
  • Appearance: Clear, colorless liquid
  • Melting Point: Approximately -63.5 °C
  • Boiling Point: Approximately 39.5-40 °C
  • Density: ~1.511 g/mL at 20 °C
  • Solubility: Miscible with various organic solvents like benzene, dichloromethane, and ether.
  • Reactivity: Highly reactive, particularly with nucleophiles.
  • Moisture Sensitivity: Reacts readily with water, hydrolyzing to trifluoroacetic acid and releasing heat. This reaction can also liberate flammable hydrogen gas under certain conditions, making it crucial to handle in dry environments.
  • Corrosivity: TFAA is corrosive and can cause severe skin and eye irritation or burns.

Safe Handling and Storage:

Due to its hazardous nature, strict safety protocols must be followed when working with Trifluoroacetic Anhydride:

  • Personal Protective Equipment (PPE): Always wear appropriate PPE, including chemical-resistant gloves (e.g., nitrile, neoprene), safety goggles or a face shield, and protective clothing.
  • Ventilation: Work in a well-ventilated area or, preferably, under a chemical fume hood to avoid inhalation of vapors.
  • Incompatibilities: TFAA is incompatible with strong oxidizing agents, water, and certain other reactive compounds. Always consult the Safety Data Sheet (SDS) for a comprehensive list.
  • Storage: Store TFAA in a tightly sealed container in a cool, dry, and well-ventilated area, away from incompatible materials and moisture. Refrigeration (2-8°C) is often recommended for long-term storage to maintain purity.
  • Spill Management: In case of a spill, evacuate the area and use appropriate absorbent materials and neutralization agents as per the SDS guidelines. Ensure proper disposal of contaminated materials.

As a leading supplier of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing not only high-quality Trifluoroacetic Anhydride but also comprehensive support regarding its safe use. We understand that for procurement managers and R&D scientists, reliable information is as crucial as the product itself. When you choose to buy TFAA from us, you are partnering with an organization that prioritizes safety, quality, and customer satisfaction. We offer competitive pricing and dependable delivery to meet your project needs. Contact us to learn more and to secure your supply of this essential chemical.