For any chemist embarking on a new synthesis project, a thorough understanding of the properties of their starting materials is fundamental. Methyl 2-Isothiocyanato Propionate (CAS: 21055-39-0) is a versatile organic synthesis intermediate, and grasping its physical and chemical characteristics is key to optimizing reaction outcomes. As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides critical data to help researchers buy and utilize this compound effectively.

Physical Properties:

Methyl 2-Isothiocyanato Propionate is typically observed as a colorless to pale yellow transparent liquid. This liquid state at room temperature makes it relatively easy to handle, measure, and transfer in a laboratory setting. Its density is reported as 1.13g/cm³, which is useful for volumetric calculations when preparing solutions or determining mass-to-volume ratios. The compound has a relatively high boiling point of 198.8ºC at 760 mmHg, indicating that it is not highly volatile under standard laboratory conditions. This characteristic is beneficial as it reduces evaporative losses during handling and reactions, and also suggests a certain degree of thermal stability within typical synthetic temperature ranges. The flash point is noted as 74ºC, a crucial parameter for safety considerations during storage and handling.

Chemical Properties and Reactivity:

The chemical identity of Methyl 2-Isothiocyanato Propionate is defined by its molecular formula C5H7NO2S and a molecular weight of 145.18000. The key functional groups are the isothiocyanate (-N=C=S) and the methyl ester (-COOCH3). The isothiocyanate group is highly electrophilic and is the primary site of reactivity. It readily undergoes nucleophilic attack by amines, alcohols, thiols, and other nucleophiles, leading to the formation of thioureas, carbamates, and thiocarbamates, respectively. This makes it an excellent building block for constructing nitrogen- and sulfur-containing heterocycles, which are prevalent in many pharmaceuticals and agrochemicals.

The methyl ester group can also be manipulated. It can be hydrolyzed to the corresponding carboxylic acid or transesterified, providing further avenues for functionalization. The combination of these reactive centers makes Methyl 2-Isothiocyanato Propionate a valuable intermediate for chemists aiming to create complex organic molecules.

Storage and Handling:

As per standard chemical practices, Methyl 2-Isothiocyanato Propionate should be stored in a cool, ventilated place to maintain its stability and purity. Proper sealing of containers is essential to prevent moisture ingress or contamination. When considering to purchase this chemical, it's important to plan for appropriate storage conditions. Our role as a manufacturer includes providing clear storage guidelines to our clients.

For those looking to buy Methyl 2-Isothiocyanato Propionate, understanding these properties is essential for successful synthesis. NINGBO INNO PHARMCHEM CO.,LTD. offers this compound with a guaranteed assay of ≥99.0% and provides detailed technical information to support your applications. Contact us for a quote and to learn more about how this versatile intermediate can benefit your research and development projects.