1,2-Difluoro-4-iodobenzene (CAS 64248-58-4) is a highly functionalized aromatic compound that plays a significant role across several advanced chemical sectors. Its unique combination of fluorine and iodine substituents on a benzene ring makes it a versatile intermediate for specialized synthesis. For professionals looking to buy this compound, understanding its synthesis pathways and broad applications is essential for strategic procurement and R&D planning.

The synthesis of 1,2-Difluoro-4-iodobenzene typically involves electrophilic iodination of 1,2-difluorobenzene. Careful control of reaction conditions, reagents, and catalysts is necessary to achieve high regioselectivity and yield. The resulting product, often obtained as a colorless to pale yellow liquid, is then purified to meet stringent industry standards, commonly with a purity of ≥98%.

The applications of 1,2-Difluoro-4-iodobenzene are diverse and impactful. In the realm of PET radiopharmaceuticals, it serves as a crucial precursor for labeling with radioisotopes like Iodine-123 or Iodine-124. These radiolabeled compounds are vital for medical imaging, aiding in the diagnosis and monitoring of various diseases. The precisely positioned fluorine atoms contribute to the overall stability and biodistribution of these diagnostic agents.

In pharmaceutical discovery and development, this difluoroiodobenzene derivative is a key intermediate for synthesizing fluorinated drug scaffolds. As mentioned earlier, fluorine incorporation can significantly improve a drug candidate's pharmacokinetic and pharmacodynamic properties. The reactive iodine moiety allows for efficient coupling reactions, enabling the rapid assembly of complex molecular architectures required for modern drug design.

Beyond pharmaceuticals, 1,2-Difluoro-4-iodobenzene is also utilized in the synthesis of specialty organic materials, including liquid crystals and advanced polymers, where its specific electronic and steric properties are advantageous. For any of these applications, securing a reliable supply of high-quality 1,2-Difluoro-4-iodobenzene from a trusted manufacturer, such as NINGBO INNO PHARMCHEM CO.,LTD., is crucial for consistent results and efficient production.