For chemists, process engineers, and procurement specialists, a thorough understanding of chemical intermediates is fundamental to successful synthesis and product development. 2-Ethylhexyl Bromide (CAS 18908-66-2) is one such intermediate, recognized for its chemical reactivity and broad utility. This article explores its primary synthesis routes, key physical and chemical properties, and essential considerations for its handling and quality assurance.

Primary Synthesis Routes: The PBr3 Method

The most industrially relevant and widely adopted method for synthesizing 2-Ethylhexyl Bromide involves the bromination of 2-ethylhexanol. This reaction typically utilizes phosphorus tribromide (PBr3) as the brominating agent. The process is favored for its high yield, operational simplicity, and scalability, making it suitable for large-volume production. Key steps often include controlled addition of PBr3 to 2-ethylhexanol at specific temperatures, followed by reflux and subsequent purification stages. The resulting product is typically obtained with high purity, often exceeding 98.0%.

Key Physical and Chemical Properties

2-Ethylhexyl Bromide is characterized by several important properties that dictate its application and handling:

  • Appearance: It is a colorless to pale yellow liquid.
  • Molecular Formula: C8H17Br.
  • Molecular Weight: Approximately 193.12 g/mol.
  • Boiling Point: Around 75-77°C at 16 mmHg, indicating it is a relatively volatile compound.
  • Density: Approximately 1.086 g/mL at 25°C.
  • Reactivity: As an alkyl bromide, it readily participates in nucleophilic substitution reactions due to the bromine atom being a good leaving group.

Purity and Quality Assurance

Ensuring the purity of 2-Ethylhexyl Bromide is critical for its intended applications, especially in pharmaceutical and advanced materials synthesis. Manufacturers utilize analytical techniques such as Gas Chromatography (GC) and Nuclear Magnetic Resonance (NMR) spectroscopy to confirm purity and identify any impurities. A purity of ≥98.0% is standard for commercial-grade material. For procurement, always request a Certificate of Analysis (CoA) to verify lot-specific quality.

Handling and Storage Considerations

While stable under normal conditions, 2-Ethylhexyl Bromide should be stored in tightly sealed containers in a cool, dry, and well-ventilated area, away from incompatible materials like strong oxidizing agents. Proper handling, including the use of appropriate personal protective equipment (PPE) such as gloves and eye protection, is recommended, as with most organic chemicals.

Choosing Your Supplier

Selecting a reliable supplier is paramount for securing a consistent and high-quality supply of 2-Ethylhexyl Bromide. We are a leading manufacturer and supplier based in China, dedicated to providing high-purity chemical intermediates. If you are looking to buy this essential compound, we invite you to inquire about our product specifications, pricing, and supply capabilities.