Tert-Butyldimethylsilyl Chloride (TBDMSCl), with the CAS number 18162-48-6, is a versatile organosilicon compound that has carved out a significant niche in organic chemistry. Known for its robust protecting group capabilities and utility in various synthetic transformations, TBDMSCl is a staple in both academic research and industrial applications. NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer and supplier in China, provides high-purity TBDMSCl, understanding its critical role in advanced chemical processes.

Chemical Profile of TBDMSCl

TBDMSCl is characterized by a silicon atom bonded to a chlorine atom, a bulky tert-butyl group, and two methyl groups. This specific structure confers several key properties. The tert-butyl group provides steric hindrance, influencing the reactivity and selectivity of the silylating agent. Physically, it typically appears as a white solid or a transparent liquid, soluble in common organic solvents like THF, dichloromethane, and DMF, but it is highly sensitive to moisture, hydrolyzing readily to form tert-butyldimethylsilanol and hydrochloric acid. This moisture sensitivity necessitates handling and storage under anhydrous conditions, often under an inert atmosphere.

Key Applications and Reactivity

The primary application of TBDMSCl is as a silylating agent to protect hydroxyl, amino, and thiol groups in organic synthesis. The resulting tert-butyldimethylsilyl ethers and derivatives are significantly more stable than their trimethylsilyl (TMS) counterparts, particularly towards acidic conditions. This enhanced stability makes TBDMSCl ideal for longer synthetic sequences. For instance, in the synthesis of complex molecules, where multiple functional groups are present, TBDMSCl can selectively protect one group while others are modified. Its use is also prevalent in carbohydrate and terpenoid chemistry.

Beyond its role as a protecting group, TBDMSCl acts as a derivatizing agent in gas chromatography/mass spectrometry (GC/MS). By converting analytes into their silyl derivatives, it enhances their volatility and chromatographic behavior, improving the accuracy and sensitivity of analyses. This capability makes it valuable in quality control and research labs.

Sourcing TBDMSCl: Quality and Value from NINGBO INNO PHARMCHEM

When you need to purchase tert-butyldimethylsilyl chloride, choosing a reliable supplier is crucial for ensuring the integrity of your research or production. NINGBO INNO PHARMCHEM CO.,LTD. offers high-quality TBDMSCl, manufactured to meet stringent purity standards. We provide competitive tert-butyldimethylsilyl chloride price, making it accessible for a wide range of applications. As a leading chemical supplier in China, we are committed to delivering consistent product quality and excellent customer service. Get a quote today and discover how our TBDMSCl can contribute to the success of your projects.