NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing comprehensive information about the chemicals we supply, including 2-Nitrobenzoic Acid (CAS 552-16-9). Understanding its chemical properties and synthesis is fundamental for its effective and safe utilization in various applications, from organic synthesis to its role as a key intermediate.

2-Nitrobenzoic Acid is an organic compound characterized by the molecular formula C7H5NO4 and a molar mass of approximately 167.12 g/mol. It typically appears as an off-white crystalline powder. Key chemical properties include a melting point ranging between 141°C to 151°C, depending on purity and isomeric composition. Its acidity, denoted by a pKa of 2.16, is significantly influenced by the electron-withdrawing nitro group, making it a stronger acid than benzoic acid itself. The presence of the nitro group in the ortho position to the carboxylic acid group imparts unique reactivity, facilitating specific reactions and influencing its physical characteristics. It exhibits solubility in water, as well as in organic solvents like alcohol and acetone.

The synthesis of 2-Nitrobenzoic Acid is commonly achieved through the oxidation of 2-nitrotoluene. This process typically involves using oxidizing agents like nitric acid under controlled conditions. The purity of the final product is critical for its intended applications, and manufacturers often employ rigorous purification methods, such as recrystallization, to achieve high assay percentages, often above 95% or even 99%. The compound is generally stable when stored properly in a cool, dry place, away from incompatible materials like strong oxidizing agents and bases.

Safety considerations are paramount when handling 2-Nitrobenzoic Acid. As indicated by its hazard statements, it can cause skin and serious eye irritation and may cause respiratory irritation. Suspected of causing genetic defects is also a noted hazard. Therefore, appropriate personal protective equipment (PPE), including gloves, eye protection, and respiratory protection, should always be used. Proper ventilation in work areas is also essential. For detailed safety information, referring to the Safety Data Sheet (SDS) provided by the supplier is highly recommended.

NINGBO INNO PHARMCHEM CO.,LTD. ensures that the 2-Nitrobenzoic Acid we supply adheres to strict quality standards, making it suitable for demanding applications in pharmaceutical synthesis, agrochemical production, and advanced organic chemistry research. By providing reliable access to detailed chemical property information and adhering to safe handling practices, we aim to support the successful application of this vital chemical intermediate.