1-Bromo-3,4-dichlorobenzene (CAS 18282-59-2) is a chemical compound that holds significant value as an intermediate in various industrial processes. Its unique structure, featuring a benzene ring with a bromine atom and two chlorine atoms at specific positions, dictates its chemical behavior and wide-ranging applications. For researchers and industrial chemists, a thorough understanding of its properties, safe handling, and synthesis is essential for effective utilization.

The physical characteristics of 1-Bromo-3,4-dichlorobenzene include a melting point typically around 24-25°C, meaning it exists as a liquid after melting under standard conditions. It presents as a clear, slightly yellow liquid. Its boiling point is approximately 124°C at 33 mm Hg, and its density is around 1.761 g/mL at 25°C. The compound is largely insoluble in water but soluble in most organic solvents, which is a common trait for halogenated aromatic hydrocarbons and influences its use in reaction media. Ensuring the purity and accurate characterization of this chemical is a priority for manufacturers and suppliers.

From a safety perspective, 1-Bromo-3,4-dichlorobenzene is classified as an irritant, with specific hazard statements indicating it can cause skin irritation, serious eye irritation, and may cause respiratory irritation. Appropriate safety precautions must be taken during handling, including wearing protective gloves, eye protection, and ensuring adequate ventilation. Safety statements like P261 (Avoid breathing dust/fume/gas/mist/vapors/spray) and P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing) are critical guidelines for its use.

The synthesis of 1-Bromo-3,4-dichlorobenzene typically involves the electrophilic bromination of 1,2-dichlorobenzene. This process requires precise control over temperature, reaction time, and the stoichiometry of reactants to maximize yield and minimize the formation of unwanted isomers. Manufacturers invest in advanced synthesis techniques and purification methods, such as distillation, to achieve the required purity levels, often exceeding 98%. Companies from China and other regions are recognized suppliers of this fine chemical, serving the global market.

The applications of 1-Bromo-3,4-dichlorobenzene are diverse, primarily serving as a building block in organic synthesis. It is extensively used in the preparation of pharmaceutical intermediates, where its structure can be modified to create complex molecules for drug development. It also finds utility in the field of electronic chemicals and as a component in various research chemicals. The demand for this compound is driven by its versatility as a functionalized aryl halide, which allows chemists to introduce specific structural elements into target molecules.

In summary, 1-Bromo-3,4-dichlorobenzene is a chemical compound of significant industrial and research importance. Its physical and chemical properties, combined with a well-understood synthesis route and adherence to safety protocols, make it a valuable asset for chemical manufacturers and researchers. As a key intermediate, it continues to support advancements across multiple scientific disciplines.