2,2-Difluoroethylamine, identified by CAS number 430-67-1, is a critical chemical intermediate renowned for its utility in synthesizing pharmaceuticals, agrochemicals, and specialty materials. Understanding its inherent properties—both physical and chemical—along with adhering to stringent safety protocols, is paramount for its effective and safe handling in laboratory and industrial settings. This article delves into these essential aspects, providing guidance for researchers and professionals working with this compound.

Physically, 2,2-Difluoroethylamine is typically described as a clear liquid, often colorless to pale yellow. Its molecular formula is C2H5F2N, and it possesses a distinct amine odor. Key properties include a boiling point in the range of 64-68.5°C and a density of approximately 1.15-1.17 g/cm³. Its volatility is marked by a significant vapor pressure, and it is classified as a flammable liquid with a low flash point, necessitating precautions against ignition sources. The solubility profile is notable for its high water solubility, attributed to the amine group's hydrogen bonding capabilities, but it also exhibits good solubility in various organic solvents like methanol and chloroform. These CAS 430-67-1 chemical properties dictate its handling and storage requirements.

Chemically, 2,2-Difluoroethylamine acts as a weak base, with a pKa around 7.09. The electron-withdrawing nature of the two fluorine atoms influences its basicity and reactivity compared to simpler amines. It readily participates in nucleophilic substitution reactions, alkylation, and amidation, making it a versatile building block in organic synthesis. The uses of 2,2-difluoroethylamine are diverse, stemming from its ability to introduce the difluoroethyl moiety, which enhances lipophilicity and metabolic stability in target molecules. Efficient 2,2-difluoroethylamine synthesis pathways are crucial for ensuring its availability for these applications.

Safety considerations are critical when handling 2,2-Difluoroethylamine. Due to its corrosive nature and potential to cause severe skin burns and eye damage, appropriate personal protective equipment (PPE) must be worn, including chemical-resistant gloves, safety goggles, and protective clothing. Inhalation of vapors can cause respiratory irritation, so work should be conducted in a well-ventilated area or under a fume hood. Its flammability also requires careful attention to avoid sparks or open flames. For those looking to source this intermediate, understanding how to buy 2,2-difluoroethylamine online from reputable suppliers who provide comprehensive safety data sheets (SDS) is essential. The careful study of fluorinated amine building blocks and their associated hazards is a vital part of safe chemical practice.