For professionals in the chemical and pharmaceutical sectors, a thorough understanding of key intermediates is essential for efficient research and production. 3-Bromo-4-methylpyridine, cataloged under CAS number 3430-22-6, is one such critical compound. This article aims to provide insights into its chemical characteristics, common synthesis pathways, and important safety precautions.

Chemically, 3-Bromo-4-methylpyridine presents as a clear, colorless to yellow liquid. Its physical properties, such as a boiling point around 199-200°C and a density of approximately 1.549 g/mL at 25°C, are important parameters for handling and processing. Its solubility in common organic solvents like chloroform and methanol further enhances its utility in various reaction setups. Understanding these properties is fundamental when considering its application in complex chemical synthesis.

The synthesis of 3-Bromo-4-methylpyridine typically involves the bromination of 4-methylpyridine. One common method described in literature utilizes reagents like bromine in the presence of aluminum chloride and potassium bromide, often carried out at elevated temperatures under an inert atmosphere. The precise control of reaction conditions, including temperature, reaction time, and reagent stoichiometry, is vital for achieving high yields and purity. The ongoing development of efficient 3-Bromo-4-methylpyridine synthesis routes is a testament to its importance.

When handling 3-Bromo-4-methylpyridine, adherence to safety guidelines is crucial. It is classified as an irritant, with hazard codes such as Xi and Xn, and associated risk statements like 36/37/38-20/21/22. Proper safety measures, including wearing appropriate personal protective equipment (PPE) and ensuring adequate ventilation, are necessary to mitigate risks. Secure storage in a cool, dry, and tightly closed container is also recommended. Chemical suppliers like NINGBO INNO PHARMCHEM CO.,LTD. provide detailed safety data sheets (SDS) to guide safe handling and usage.

The consistent availability of high-quality 3-Bromo-4-methylpyridine is vital for numerous research projects and industrial applications, particularly in the pharmaceutical industry where it serves as a key intermediate. Its role in building complex molecules, including precursors for proton pump inhibitors, underscores its significance. By understanding its synthesis and properties, chemists can effectively incorporate this valuable compound into their synthetic strategies.