In the intricate world of organic synthesis, specific molecules act as linchpins, enabling the creation of complex and valuable compounds. One such critical intermediate is N-(5-CHLORO-2-PYRIDYL)TRIFLIMIDE, also known by its CAS number 145100-51-2 and other synonyms like Bistrifluoromethylsulfonylaminochloropyridine. This compound is a potent reagent that plays a pivotal role in advanced synthetic pathways. For researchers and procurement specialists looking to buy this chemical, understanding its applications is key to appreciating its value.

The Core Function: Vinyl Triflate Formation

The most prominent application of N-(5-CHLORO-2-PYRIDYL)TRIFLIMIDE is its function as a precursor for the synthesis of vinyl trifluoromethanesulfonates. This reaction is typically achieved by reacting the triflimide with corresponding ketoenols or dienols. The outcome is the formation of highly reactive and versatile vinyl triflates. These triflates are indispensable in modern synthetic chemistry for several reasons:

  • Cross-Coupling Reactions: Vinyl triflates are excellent substrates for a wide array of transition-metal-catalyzed cross-coupling reactions. This includes widely used methodologies like the Suzuki, Stille, Heck, and Sonogashira couplings. These reactions allow for the precise formation of carbon-carbon bonds, enabling the construction of complex molecular frameworks essential for pharmaceuticals, agrochemicals, and materials science.
  • Versatility: The ability to easily functionalize the vinyl group after the triflate formation opens up numerous synthetic avenues.

Beyond Vinyl Triflates: Other Synthetic Uses

While its role in vinyl triflate synthesis is primary, the inherent reactivity of the triflimide group and the pyridine core suggests broader potential applications. As a powerful electrophile and electron-withdrawing moiety, it could potentially be utilized in other activation or functionalization reactions, depending on the specific reaction conditions and substrate. For laboratories engaged in novel synthetic methodology development, exploring the full reactivity profile of this compound can lead to new discoveries.

Procuring N-(5-CHLORO-2-PYRIDYL)TRIFLIMIDE from a Manufacturer

When seeking to acquire N-(5-CHLORO-2-PYRIDYL)TRIFLIMIDE, engaging directly with a reputable manufacturer or a trusted supplier is recommended. Factors to consider include:

  • Purity: Ensure the product meets the specified purity, typically 98%. High purity is critical for predictable reaction outcomes.
  • Price: Obtaining competitive price quotes, especially for bulk quantities, is essential for cost-effective R&D and production.
  • Availability: A consistent and reliable supply chain is vital for uninterrupted research and manufacturing.
  • Technical Support: Knowledgeable suppliers can offer valuable insights into product handling, safety, and potential applications.

For those looking to buy this crucial intermediate, working with experienced chemical providers, particularly those specializing in fine chemicals and intermediates from regions like China, can ensure both quality and competitive pricing. The ability to obtain this compound readily allows researchers to push the boundaries of chemical synthesis and develop next-generation products.