In the intricate landscape of chemical synthesis, intermediate compounds serve as the crucial linchpins that enable the creation of complex molecules. Among these indispensable building blocks is 2-Fluoro-N-methylaniline (CAS 1978-38-7), a compound whose unique properties and versatile applications make it highly sought after. NINGBO INNO PHARMCHEM CO.,LTD. is committed to exploring and supplying such vital chemicals, ensuring that researchers and manufacturers have access to materials that drive progress. This piece focuses on the synthesis pathways and fundamental properties of 2-Fluoro-N-methylaniline, offering insights into why it is a preferred choice for various chemical endeavors.

Synthesis Strategies for 2-Fluoro-N-methylaniline

The efficient synthesis of 2-Fluoro-N-methylaniline is critical for its widespread use. One common and effective method involves the N-methylation of 2-fluoroaniline. A notable green chemistry approach utilizes dimethyl carbonate as a methylating agent in the presence of a basic molecular sieve catalyst, such as NaY. This method is appreciated for its high yields, often exceeding 99.4%, and its environmentally friendly nature, minimizing the use of hazardous reagents. The process typically involves refluxing the reactants for approximately 11-12 hours, with reaction progress monitored by Gas Chromatography (GC). Post-reaction, the catalyst is filtered, and the product is purified through rectification. This method efficiently produces 2-Fluoro-N-methylaniline with high GC purity (around 99.2%), while by-products like N,N-dimethyl o-fluoroaniline are kept to a minimum (around 0.29%). For those looking to purchase 2-Fluoro-N-methylaniline, understanding these synthesis routes assures quality and efficiency.

Key Properties for Optimal Application

The value of 2-Fluoro-N-methylaniline lies not only in its synthesis but also in its inherent properties. As a yellow clear liquid, its assay of ≥99.0% guarantees a high level of purity, which is essential for precise chemical reactions. Its molecular formula, C7H8FN, and molecular weight of approximately 125.14 contribute to its predictable behavior in various reactions. The compound exhibits a density of 1.106 g/cm³, a boiling point of 87-88°C, and a flash point of 62.9°C. These characteristics make it suitable for use in a controlled environment, ensuring safety and efficacy. The low moisture content, typically ≤0.2%, further enhances its stability and shelf-life, making it a reliable component for complex projects. These attributes solidify its position as one of the key organic synthesis intermediates, enabling precise transformations in downstream processes.

NINGBO INNO PHARMCHEM CO.,LTD. as a Trusted Supplier

At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to providing the chemical community with high-quality intermediates. Our focus on rigorous quality control and efficient supply chain management ensures that customers receive products like 2-Fluoro-N-methylaniline that meet exacting standards. We understand the critical role this compound plays in areas such as pharmaceutical development and the creation of advanced agrochemicals. By ensuring the availability of high-purity 2-Fluoro-N-methylaniline, we empower chemists and manufacturers to pursue their research and production goals with confidence. Whether you require small quantities for research or bulk orders for industrial applications, NINGBO INNO PHARMCHEM CO.,LTD. is your reliable partner for essential chemical building blocks.

In summary, the effective synthesis and desirable properties of 2-Fluoro-N-methylaniline make it an indispensable tool in modern chemistry. Its application as a versatile intermediate in creating complex molecules, from pharmaceuticals to agrochemicals, highlights its ongoing relevance and importance in scientific advancement.