For procurement managers and R&D scientists in the chemical and pharmaceutical industries, sourcing high-quality intermediates is paramount. Trimethylene oxide (CAS 503-30-0), also known as oxetane, stands out as a crucial building block due to its unique four-membered ring structure and resulting reactivity. This article aims to guide you through understanding its significance and how to effectively purchase it from reputable suppliers.

What is Trimethylene Oxide?

Trimethylene oxide is a cyclic ether characterized by a four-membered ring containing three carbon atoms and one oxygen atom. This structural feature imparts a considerable degree of ring strain, making it more reactive than its larger cyclic ether counterparts like tetrahydrofuran. It typically presents as a clear, colorless liquid with a characteristic odor. Its chemical formula is C3H6O and it has a molecular weight of 58.08 g/mol.

Key Applications in the Industry

The versatility of Trimethylene oxide makes it a sought-after intermediate across several sectors:

  • Pharmaceutical Synthesis: Its ability to readily undergo ring-opening reactions with various nucleophiles, such as Grignard reagents and organolithium compounds, allows for the introduction of the 3-oxypropylene moiety into complex drug molecules. This is vital for developing novel active pharmaceutical ingredients (APIs).
  • Polymer Science: Trimethylene oxide can be polymerized to create polyethers with specific properties or incorporated into copolymers, leading to advanced materials used in coatings, adhesives, and specialty plastics.
  • Fine Chemicals: As a building block, it facilitates the synthesis of a wide array of fine chemicals, including agrochemicals, flavors, fragrances, and performance additives, contributing to product innovation.

Sourcing Trimethylene Oxide: What to Look For

When procuring Trimethylene oxide, several factors are critical for ensuring successful outcomes in your synthesis:

  • Purity: Look for products with high purity, typically 97% or 99%, to ensure predictable reaction yields and minimize side products. Manufacturers often provide detailed specifications and Certificates of Analysis (CoA).
  • Supplier Reliability: Partnering with established manufacturers and suppliers based in China, such as NINGBO INNO PHARMCHEM CO.,LTD., guarantees consistent quality and a stable supply chain. Reliability is key for uninterrupted production schedules.
  • Pricing and Availability: Understanding the market price for Trimethylene oxide and its availability is crucial for budget management. Requesting quotes for bulk purchases can often lead to significant cost savings.
  • Safety Data: Always obtain and review the Safety Data Sheet (SDS) for Trimethylene oxide. As a flammable liquid with potential health hazards, understanding proper handling, storage, and disposal procedures is essential.

How to Buy Trimethylene Oxide

To purchase Trimethylene Oxide, identifying reputable manufacturers is the first step. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing high-quality chemical intermediates. You can initiate a purchase by:

  1. Visiting the supplier's website and submitting an inquiry for a quote.
  2. Specifying the required quantity, purity, and delivery timeline.
  3. Requesting a sample to verify quality before committing to a larger order.
  4. Discussing payment terms and shipping options, including Incoterms like FOB or CFR, to suit your logistical needs.

By focusing on purity, supplier reliability, and competitive pricing, procurement professionals can secure a consistent supply of Trimethylene Oxide, a vital component for advancing chemical synthesis and product development. For your next requirement, consider reaching out to experienced suppliers in China to get a competitive price and reliable supply.