In the intricate world of chemical synthesis, specific molecules stand out for their unique properties and broad applicability. 2-Bromo-4-trifluoromethoxy-1-iodobenzene, identified by its CAS number 883546-30-3, is one such compound. As a key organic intermediate, it offers synthetic chemists a powerful tool for constructing complex molecular architectures. Its utility is particularly pronounced in cutting-edge research and development across pharmaceuticals and materials science, making it a compound of significant interest for scientists and procurement specialists alike.

Chemical Structure and Reactivity of CAS 883546-30-3

The molecule's structure is key to its versatility. It features a benzene ring substituted with three distinct functional groups: a bromine atom, an iodo atom, and a trifluoromethoxy group (-OCF3). Each of these groups imparts specific reactivity and properties:

  • Iodo Group: The iodine atom is highly reactive in various cross-coupling reactions, such as Suzuki, Sonogashira, and Heck couplings. These reactions are fundamental for forming carbon-carbon bonds, essential for building complex organic frameworks.
  • Bromo Group: Similarly, the bromine atom can participate in a variety of coupling reactions and nucleophilic substitutions, offering alternative or complementary pathways for molecular construction.
  • Trifluoromethoxy Group: The -OCF3 group is electron-withdrawing and can influence the electronic properties and lipophilicity of the molecule. In pharmaceutical applications, such fluorinated groups are often incorporated to enhance metabolic stability, bioavailability, and binding affinity.

This combination of functional groups makes 2-Bromo-4-trifluoromethoxy-1-iodobenzene an ideal candidate for creating diverse chemical libraries and specialized compounds.

Key Applications Driving Demand

The demand for this intermediate is driven by its critical roles in several advanced fields:

  • Pharmaceutical Intermediates: It serves as a vital building block in the synthesis of numerous drug candidates. The trifluoromethoxy group, in particular, is frequently incorporated into pharmaceutical molecules to improve their pharmacokinetic properties. Researchers and manufacturers actively purchase this compound to develop novel APIs.
  • OLED and Electronic Materials: The unique electronic properties conferred by the trifluoromethoxy group and the halogen substituents make this compound valuable in the development of organic light-emitting diode (OLED) materials, conductive polymers, and other advanced electronic components.
  • Agrochemicals: Similar to pharmaceuticals, fluorinated compounds often exhibit enhanced biological activity and stability, making them useful in the agrochemical industry for developing new pesticides and herbicides.
  • Research and Development: As a versatile synthon, it is extensively used in academic and industrial R&D labs for exploring new chemical reactions and synthesizing novel compounds with potential applications across various scientific disciplines.

Procurement Strategies

For researchers and businesses needing this compound, understanding the supply chain is key. Many leading manufacturers and suppliers, particularly those in China, offer 2-Bromo-4-trifluoromethoxy-1-iodobenzene with high purity (e.g., 97% or 99%). When planning to buy, consider obtaining a quote for bulk quantities from a reliable manufacturer to ensure cost-effectiveness and consistent availability for your ongoing projects.

In conclusion, the chemical intermediate CAS 883546-30-3 is an indispensable component for innovation in chemistry. Its diverse reactivity and the beneficial properties of its substituents ensure its continued importance in the development of advanced pharmaceuticals and materials.