Nicotinaldehyde, also known as 3-Pyridinecarboxaldehyde (CAS 500-22-1) and 3-formylpyridine, is a highly versatile chemical compound that serves as a fundamental intermediate in various industrial processes. As a clear yellow to light brown liquid, its chemical structure, featuring a pyridine ring with an aldehyde group, endows it with unique properties that are invaluable for synthetic chemistry.

The core of nicotinaldehyde's utility lies in its reactivity. Its aldehyde functional group readily undergoes reactions with various nucleophiles, including amines, alcohols, and hydrazines. This makes it a prime candidate for complex organic syntheses, essential for creating specialized molecules used across different sectors. Understanding the 3-Pyridinecarboxaldehyde reactivity is key for chemists aiming to optimize synthetic pathways.

In the pharmaceutical sector, nicotinaldehyde is a crucial pharmaceutical intermediate. It is instrumental in the synthesis of a broad spectrum of drug candidates, particularly those with potential anti-inflammatory and anti-cancer activities. Its connection to niacin, a B vitamin, also makes it relevant in developing related biochemicals and therapeutic agents.

The agrochemical industry also relies heavily on this compound. As an important agrochemical intermediate, nicotinaldehyde is used in the production of pesticides and herbicides that are critical for modern agriculture. Its role in developing more effective and sustainable crop protection solutions underscores its significance.

Beyond these major sectors, nicotinaldehyde is recognized for its unique property of being a constituent of tobacco smoke, contributing to the sensory characteristics of tobacco products. This application further illustrates the compound's diverse chemical profile.

For manufacturers and researchers working with nicotinaldehyde, proper handling and storage are essential. The compound is air-sensitive and is typically stored under refrigerated conditions (2-8°C) to maintain its purity and reactivity. This ensures the reliability of subsequent synthetic steps.

The CAS number 500-22-1 serves as a unique identifier for nicotinaldehyde, facilitating its global trade and research. The continuous demand for this compound from various 3-Pyridinecarboxaldehyde suppliers highlights its indispensable role in chemical innovation and product development across the pharmaceutical, agrochemical, and fine chemical industries.