As chemists, we are constantly on the lookout for reliable and versatile chemical intermediates that can unlock new synthetic pathways and enable the creation of novel compounds. 2-Methyl-5-propionylfuran, cataloged under CAS number 10599-69-6, is a compound that merits closer examination due to its intriguing structure and broad applicability. For those in R&D and synthesis labs, understanding its characteristics is key to unlocking its full potential.

Structural Features and Chemical Identity

At its core, 2-Methyl-5-propionylfuran is a derivative of furan, a five-membered heterocyclic aromatic ring containing one oxygen atom. The compound is further functionalized with a methyl group (-CH3) at the 5-position and a propionyl group (-COCH2CH3) at the 2-position of the furan ring. This bifunctional nature, combining the aromatic furan system with a ketone carbonyl, dictates its chemical behavior. Its molecular formula is C8H10O2, yielding a molecular weight of 138.16 g/mol. The presence of the electron-donating methyl group and the electron-withdrawing propionyl group influences the electron distribution within the furan ring, impacting its reactivity in electrophilic aromatic substitution and other reactions.

Physical and Chemical Properties for Synthesis

From a practical standpoint for laboratory work, the physical properties of 2-Methyl-5-propionylfuran are important. It is typically described as a clear yellow liquid, with a boiling point of 72°C at 5mmHg. This relatively low boiling point under vacuum suggests it can be handled and purified using standard distillation techniques. Its refractive index is measured between 1.5037 and 1.5057. Solubility data indicates slight solubility in solvents like acetonitrile and chloroform, which are common organic solvents used in synthesis and analysis. These properties make it amenable to various reaction conditions and purification methods, making it a practical choice when you need to buy chemical intermediates for complex syntheses.

Reactivity and Synthetic Utility

The propionyl ketone moiety can undergo standard carbonyl chemistry, such as nucleophilic addition, condensation, and reduction reactions. The furan ring itself can participate in cycloaddition reactions or undergo electrophilic substitution, though its reactivity can be modulated by the existing substituents. This dual reactivity profile makes 2-Methyl-5-propionylfuran an attractive intermediate for chemists aiming to build complex molecular frameworks. For example, it can be used in the synthesis of other heterocycles, pharmaceutical precursors, or even flavour compounds. When seeking to purchase this chemical, understanding these reactive sites allows chemists to design efficient synthetic routes.

Sourcing High-Quality Intermediates

For chemists engaged in demanding research and development projects, the purity and consistency of their starting materials are non-negotiable. A high purity of 97% for 2-Methyl-5-propionylfuran is often specified, ensuring that experimental results are accurate and reproducible. Manufacturers who provide detailed analytical data, such as Certificates of Analysis, are preferred. If you are looking to buy this intermediate, considering suppliers who can offer technical support and reliable availability from established manufacturing bases, such as China, is a wise strategy. This ensures your research progresses without interruption due to material supply issues.

In summary, 2-Methyl-5-propionylfuran (CAS 10599-69-6) is a valuable tool in the organic chemist's arsenal. Its well-defined structure, predictable reactivity, and accessible physical properties make it a sought-after intermediate for a wide range of synthetic applications.