In the vast landscape of chemical synthesis, certain compounds stand out for their unique structural features and broad applicability. 3,5-Bis(trifluoromethyl)iodobenzene, also known as 1-Iodo-3,5-bis(trifluoromethyl)benzene and identified by CAS Number 328-73-4, is one such critical intermediate. This article aims to provide chemists, researchers, and procurement professionals with a clear understanding of its properties, uses, and why sourcing it from reliable suppliers is essential.

Chemical Identity and Properties

3,5-Bis(trifluoromethyl)iodobenzene is an aromatic organic compound characterized by a benzene ring substituted with an iodine atom and two trifluoromethyl (-CF₃) groups at the 3 and 5 positions. Its key identifiers and properties include:

  • Chemical Name: 1-Iodo-3,5-bis(trifluoromethyl)benzene
  • CAS Number: 328-73-4
  • Synonyms: 3,5-Bis(trifluoromethyl)iodobenzene, 1-iodo-3,5-di(trifluoromethyl)benzene
  • Molecular Formula: C₈H₃F₆I
  • Molecular Weight: Approximately 340.004 g/mol
  • Appearance: Typically described as a light yellow liquid.
  • Purity: High purity, commonly specified as ≥98.0% (GC), is essential for its demanding applications.
  • Key Physical Data: Density around 1.9 g/cm³, boiling point approximately 183.9 °C at 760 mmHg.

The presence of the electron-withdrawing trifluoromethyl groups significantly impacts the reactivity of the aromatic ring and the iodine atom. This makes the compound an excellent substrate for various organometallic cross-coupling reactions.

Essential Applications in Synthesis

The versatility of 3,5-Bis(trifluoromethyl)iodobenzene makes it a sought-after intermediate across several industries:

  • Organic Synthesis: It serves as a fundamental building block for synthesizing more complex organic molecules. Its reactive iodine allows for efficient functionalization via reactions like Suzuki, Stille, or Buchwald-Hartwig couplings.
  • Pharmaceutical Intermediates: The compound is crucial in the synthesis of Active Pharmaceutical Ingredients (APIs). Introducing trifluoromethylated aromatic rings can enhance drug efficacy, improve metabolic stability, and increase lipophilicity, thereby improving drug performance.
  • Agrochemicals: It is employed in the development of new pesticides, herbicides, and fungicides, contributing to more potent and stable crop protection agents.
  • Material Science: Researchers utilize it to create specialty polymers, electronic materials, and advanced coatings due to the unique thermal, chemical, and electronic properties imparted by the fluorinated aromatic structure.

Why Source from a Reliable Manufacturer?

Given its critical role, ensuring the quality and consistent availability of 3,5-Bis(trifluoromethyl)iodobenzene is paramount. When you choose to buy this intermediate, partnering with a reputable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. guarantees access to high-purity material that meets rigorous specifications. We understand the importance of reliable supply chains for R&D and industrial production. Our commitment is to provide this essential chemical intermediate with exceptional quality control and competitive pricing, ensuring your synthetic projects proceed without interruption.

By understanding the chemical identity and application breadth of 3,5-Bis(trifluoromethyl)iodobenzene, professionals can make informed decisions regarding its procurement and utilization. If you are looking to buy this versatile intermediate, consider the benefits of partnering with an experienced and trusted manufacturer.