Understanding the chemical intricacies of specialized molecules is fundamental to their effective application in research and industry. Fmoc-L-3-Trifluoromethylphenylalanine, identified by CAS number 205526-27-8, is a prime example of such a compound, offering unique properties that make it invaluable in fields like peptide synthesis and medicinal chemistry. NINGBO INNO PHARMCHEM CO., LTD. provides this critical intermediate, ensuring researchers have access to its detailed chemical profile for informed utilization.

At its core, Fmoc-L-3-Trifluoromethylphenylalanine is a derivative of the amino acid phenylalanine, modified with two key features: the N-terminal Fmoc (9-fluorenylmethoxycarbonyl) protecting group and a trifluoromethyl (CF3) group substituted at the meta (3-) position of the phenyl ring. Its molecular formula is C25H20F3NO4, with a molecular weight of approximately 455.43 g/mol. This structure is crucial for its function, particularly in solid-phase peptide synthesis (SPPS). The Fmoc group provides temporary protection for the alpha-amino group, allowing for controlled, stepwise addition of amino acids. The trifluoromethyl group, a potent electron-withdrawing substituent, significantly influences the electronic distribution and lipophilicity of the molecule, which in turn affects the properties of the peptides it forms.

Physically, Fmoc-L-3-Trifluoromethylphenylalanine typically appears as a white to off-white solid or powder. Its melting point is generally reported in the range of 147-157°C, indicating a stable solid form under standard laboratory conditions. The compound is usually supplied with a high purity level, often exceeding 97% as determined by HPLC, which is essential for the success of sensitive synthetic processes. Its solubility characteristics vary, but it is generally soluble in common organic solvents used in peptide synthesis, such as dimethylformamide (DMF) and dichloromethane (DCM).

The applications of Fmoc-L-3-Trifluoromethylphenylalanine are predominantly within the realm of peptide synthesis. As a non-natural amino acid, it allows for the incorporation of a modified phenylalanine residue into peptide sequences. This modification can lead to peptides with enhanced biological activity, improved metabolic stability against enzymatic degradation, increased lipophilicity for better cell membrane penetration, or altered binding affinities to target receptors. These modified peptides find extensive use in pharmaceutical research for drug discovery, in the development of novel diagnostic agents, and in various biochemical studies aimed at understanding complex biological pathways.

NINGBO INNO PHARMCHEM CO., LTD. plays a vital role in supplying this high-value chemical intermediate. Our manufacturing processes are designed to yield Fmoc-L-3-Trifluoromethylphenylalanine with the purity and consistency required for demanding research and development projects. By providing access to detailed chemical information and high-quality products, we empower scientists to leverage the unique properties of this compound effectively. The precise nature of its chemical profile makes it an indispensable component for creating peptides with tailored characteristics.

In conclusion, Fmoc-L-3-Trifluoromethylphenylalanine is a sophisticated chemical building block with a well-defined profile. Its structural features, including the Fmoc protection and the trifluoromethyl substituent, equip it for advanced peptide synthesis applications. NINGBO INNO PHARMCHEM CO., LTD. is committed to supplying this essential compound, contributing to scientific innovation and the development of novel peptide-based solutions.