For chemists and procurement managers involved in organic synthesis, selecting the correct coupling reagents is paramount. Among the most versatile and widely used are carbodiimides, with 1,3-Diisopropylcarbodiimide (DIC) often standing out. This article delves into why DIC is a preferred choice for many applications, from peptide synthesis to amide bond formation, and offers insights on how to procure this essential chemical.

When comparing carbodiimides, DIC (CAS 693-13-0) offers distinct advantages. Unlike its solid counterpart, DCC (N,N'-Dicyclohexylcarbodiimide), DIC is a liquid. This physical state makes it significantly easier to handle, measure, and dose accurately in a laboratory or production setting. For researchers and manufacturers focused on efficiency and precision, the liquid nature of DIC simplifies reaction setup and reduces handling errors. This ease of use is a critical factor for anyone looking to buy 1,3-Diisopropylcarbodiimide for frequent use.

The primary application driving demand for DIC is its efficacy as a coupling reagent. It efficiently activates carboxylic acids, enabling them to react with nucleophiles like amines and alcohols to form amide and ester bonds, respectively. In peptide synthesis, DIC is particularly valuable. It can be used in both solution-phase and solid-phase methodologies. For solid-phase peptide synthesis (SPPS), DIC offers advantages over DCC because the urea byproduct it forms is soluble in common organic solvents, avoiding the precipitation issues that can complicate purification when using DCC. This makes DIC a more amenable reagent for large-scale synthesis where purification efficiency is key.

Furthermore, DIC's utility extends to the synthesis of various heterocycles and ureas. Its ability to promote efficient bond formation under relatively mild conditions makes it a cornerstone reagent for many complex organic synthesis pathways. As a leading manufacturer and supplier of specialty chemicals in China, NINGBO INNO PHARMCHEM is committed to providing high-purity DIC (≥99.0% GC) to meet the demanding requirements of our global clientele. We understand the importance of reliable sourcing for critical intermediates, and our DIC ensures consistent performance.

When considering a purchase, looking for a reliable manufacturer and supplier is crucial. Factors such as product purity, consistent batch-to-batch quality, competitive DIC price, and secure supply chain are essential. For those seeking to buy 1,3-Diisopropylcarbodiimide online or in bulk, NINGBO INNO PHARMCHEM offers a direct route to a premium chemical. Our commitment to quality control and customer satisfaction makes us a go-to source for your chemical synthesis needs. Explore our offerings and experience the difference of sourcing from a trusted partner.