For procurement professionals and R&D scientists in the pharmaceutical and biotechnology sectors, understanding the pricing and availability of critical reagents like Fmoc-L-Valine (CAS 68858-20-8) is crucial for effective budget management and project planning. This essential amino acid derivative, vital for peptide synthesis and as a pharmaceutical intermediate, is subject to various market dynamics.

The cost of Fmoc-L-Valine is influenced by several factors. Firstly, the purity level significantly impacts pricing. Higher purity grades, typically exceeding 99.0% by HPLC, command higher prices due to the rigorous purification processes involved. The scale of purchase also plays a role; bulk orders generally benefit from lower per-unit costs compared to smaller laboratory quantities. Raw material costs for L-valine and the Fmoc protecting agent, along with manufacturing overheads and R&D investment, also contribute to the final price.

Availability is another key consideration. While Fmoc-L-Valine is a widely used compound, supply chain disruptions, geopolitical factors, and fluctuating demand can affect its ready availability. Therefore, establishing a relationship with a reliable manufacturer that can ensure consistent stock and production capacity is paramount. Many buyers find that sourcing from China provides a significant advantage in terms of both price competitiveness and supply stability.

Chinese chemical manufacturers have become leading global suppliers of fine chemicals and pharmaceutical intermediates, including Fmoc-L-Valine. Their extensive production facilities, optimized manufacturing processes, and competitive labor costs allow them to offer Fmoc-L-Valine at attractive price points. Moreover, many Chinese suppliers have invested heavily in quality control systems, ensuring that their products meet international standards, often with detailed Certificates of Analysis (CoA) provided with each shipment.

When evaluating suppliers, buyers should compare not only the price but also the quality assurance measures, lead times, and overall reliability. It is advisable to request quotes from multiple manufacturers and to assess their responsiveness and transparency. For critical projects, securing long-term supply agreements can help lock in pricing and ensure continuity of supply, mitigating the risks associated with market volatility.

In summary, while the price of Fmoc-L-Valine (CAS 68858-20-8) is influenced by purity and volume, sourcing from established China-based manufacturers can offer a cost-effective and reliable solution. By understanding the factors affecting pricing and availability, buyers can make informed decisions to secure this vital chemical intermediate for their synthesis and manufacturing needs, ensuring project success and efficient resource allocation.