Peptide synthesis is a cornerstone of modern biotechnology and pharmaceuticals, enabling the creation of complex therapeutic proteins, diagnostic tools, and research reagents. The efficiency and success of peptide synthesis rely heavily on the quality and purity of the reagents used, particularly the amino acids, coupling agents, and linkers. Octadecanedioic Acid Mono-tert-butyl Ester, with CAS number 843666-40-0, is a specialized linker that has found increasing utility in peptide chemistry. As a dedicated manufacturer and supplier, we are proud to offer this high-purity intermediate to researchers and chemical manufacturers worldwide.

Octadecanedioic Acid Mono-tert-butyl Ester, also referred to as Boc-C16-COOH, is an aliphatic diester derivative. Its structure features a long C16 carbon chain terminated by a carboxylic acid group and a tert-butyl ester. This bifunctional nature makes it an exceptionally useful linker in peptide synthesis. The carboxylic acid can be activated using standard peptide coupling reagents and reacted with the N-terminus of a growing peptide chain or with the side chain of a modified amino acid. The tert-butyl ester group serves as a robust protecting group for the second carboxylic acid. It can be selectively cleaved under acidic conditions, typically trifluoroacetic acid (TFA), to expose the second carboxyl group for further conjugation or functionalization. This ability to introduce a linker with orthogonal protecting groups is invaluable for building complex peptide structures or conjugating peptides to other molecules.

When engaging in peptide synthesis, the purity of every reagent is critical to avoid side reactions and ensure the final product's integrity. Our commitment as a manufacturer is to provide Octadecanedioic Acid Mono-tert-butyl Ester that meets the highest purity standards, ensuring optimal performance in your synthesis protocols. By choosing to buy from a reliable supplier, you mitigate the risk of impurities interfering with coupling reactions or affecting the final peptide sequence. The competitive price we offer for this compound, along with its availability from our China-based manufacturing facility, makes it an accessible and strategic choice for peptide synthesis laboratories.

The utility of Octadecanedioic Acid Mono-tert-butyl Ester in peptide synthesis is broad. It can be used to create peptide conjugates, such as peptide-drug conjugates (PDCs) or peptide-polymer conjugates, by linking the peptide to a therapeutic agent or a solubilizing polymer like polyethylene glycol (PEG). Its long aliphatic chain can also influence the lipophilicity and pharmacokinetic properties of the resulting conjugate. For researchers focused on solid-phase peptide synthesis (SPPS), incorporating this linker onto a resin or using it as a building block allows for the introduction of specific functionalities at predefined points in the peptide sequence.

In conclusion, Octadecanedioic Acid Mono-tert-butyl Ester is an indispensable linker for advanced peptide synthesis. We provide this essential reagent with guaranteed high purity and competitive pricing, backed by our manufacturing expertise. If you are looking to purchase reliable Boc-C16-COOH for your peptide synthesis projects, partner with us for a consistent and high-quality supply.