Fmoc-Gly-Gly-OH, a dipeptide derivative with CAS number 35665-38-4, represents a significant molecule in the sophisticated landscape of peptide chemistry. Its molecular structure, featuring two glycine units linked together and protected by the Fmoc group, makes it an indispensable tool for researchers engaged in the synthesis of peptides and related complex biomolecules.

The Fmoc protection strategy is central to the utility of Fmoc-Gly-Gly-OH. This protecting group ensures that the amine terminus of the dipeptide remains masked during coupling reactions, preventing unwanted side reactions and facilitating controlled chain elongation. Upon completion of a coupling step, the Fmoc group can be readily removed using mild basic conditions, such as piperidine, regenerating a free amine ready for the next amino acid addition. This ease of handling is a key reason why it is a favored component among Fmoc-Amino Acids.

Glycine, being the simplest amino acid, confers a unique molecular characteristic to Fmoc-Gly-Gly-OH: flexibility. When this dipeptide unit is incorporated into a larger peptide chain, it can contribute to the overall conformational adaptability of the molecule. This flexibility is often crucial for peptides to achieve their correct three-dimensional structures, which in turn dictates their biological activity. Consequently, Fmoc-Gly-Gly-OH is highly sought after for applications in peptide synthesis and drug discovery.

Beyond its primary use in peptide synthesis, the molecular architecture of Fmoc-Gly-Gly-OH also makes it valuable in other advanced applications, such as the design of linkers for antibody-drug conjugates (ADCs). As a dipeptide building block, it can contribute to the stability and cleavability of the linker, a critical factor for the effective delivery of cytotoxic agents. Sourcing this compound from a reliable supplier in China like NINGBO INNO PHARMCHEM CO.,LTD. ensures the molecular integrity and purity required for these sensitive applications.

For scientists looking to procure Fmoc-Gly-Gly-OH, understanding its molecular significance clarifies its value in research. NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer in China, offers this essential chemical at a competitive price, supporting the advancement of peptide chemistry and related scientific disciplines. We are committed to providing the building blocks that drive innovation.