In the realm of specialized chemical synthesis, particularly for applications in pharmaceuticals and advanced research, the precise technical specifications of a reagent are paramount. Fmoc-Gly-OPfp, a key intermediate in peptide synthesis, is no exception. Understanding its detailed properties, such as purity, molecular weight, and solubility, is crucial for procurement managers and R&D scientists when selecting a supplier.

Fmoc-Gly-OPfp, identified by its CAS number 86060-85-7, is chemically named (2,3,4,5,6-pentafluorophenyl) 2-(9H-fluoren-9-ylmethoxycarbonylamino)acetate. Its molecular formula is C23H14F5NO4, and its molecular weight is approximately 463.35 g/mol. These fundamental parameters are the starting point for any technical evaluation. The presence of fluorine atoms in the pentafluorophenyl ester moiety contributes to its high reactivity, making it an excellent activating group for amide bond formation during peptide coupling.

However, the most critical specification for Fmoc-Gly-OPfp, especially when used in pharmaceutical research and peptide synthesis, is its purity. Leading manufacturers typically guarantee a purity of 98% or higher, often determined by High-Performance Liquid Chromatography (HPLC) or Nuclear Magnetic Resonance (NMR) spectroscopy. This high purity ensures that minimal unwanted side products are incorporated into the growing peptide chain. Even small amounts of related impurities, such as free glycine or partially reacted esters, can lead to complex purification challenges and potentially compromise the biological activity or therapeutic efficacy of the final peptide. Therefore, when you buy Fmoc-Gly-OPfp online, always request and scrutinize the Certificate of Analysis (COA) provided by the supplier.

Solubility is another important technical consideration. Fmoc-Gly-OPfp is typically soluble in common organic solvents used in SPPS, such as Dimethyl Sulfoxide (DMSO) and N,N-Dimethylformamide (DMF). While some sources may indicate solubility in specific concentrations (e.g., ≥51.1 mg/mL in DMSO), understanding its behavior in your specific synthesis solvent system is key. Incompatibility or poor solubility can lead to inefficient coupling reactions and incomplete incorporation of the amino acid.

Choosing a reputable Fmoc-Gly-OPfp manufacturer or peptide synthesis reagents supplier means obtaining a product that consistently meets these rigorous technical standards. These suppliers often have robust quality assurance protocols in place, ensuring that each batch of Fmoc-Gly-OPfp adheres to the stated specifications. This technical reliability is invaluable for reproducible research and scalable production. The CAS 86060-85-7 price should always be considered in conjunction with these critical technical details, ensuring that cost-effectiveness does not come at the expense of product integrity.

In summary, the technical profile of Fmoc-Gly-OPfp—its molecular weight, formula, solubility, and, most importantly, its purity—are vital for its successful application in peptide synthesis and drug discovery. By prioritizing suppliers who provide comprehensive technical data and maintain high-quality standards, researchers and manufacturers can ensure the integrity and efficiency of their synthetic processes.