For professionals in the pharmaceutical and biotech industries, understanding the chemical building blocks is fundamental to successful research and development. Today, we focus on a critical compound: Fmoc-Trp(Boc)-OH, identified by its CAS number 143824-78-6. This derivative of L-tryptophan is indispensable for anyone involved in solid-phase peptide synthesis (SPPS), offering a reliable method to incorporate tryptophan into peptide sequences while protecting against common synthesis issues. As a dedicated Fmoc-Trp(Boc)-OH supplier in China, we aim to provide clarity on its importance and the benefits of securing a consistent supply.

The designation CAS 143824-78-6 uniquely identifies Fmoc-Trp(Boc)-OH, a specialized amino acid derivative crucial for modern peptide chemistry. Its full chemical name, (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoic acid, highlights its structure: L-tryptophan protected at the alpha-amino group with Fmoc and at the indole nitrogen with a Boc group. This dual protection is the key to its utility. Unlike unprotected tryptophan, which can undergo side reactions like alkylation or sulfonation during the Fmoc deprotection steps in SPPS, Fmoc-Trp(Boc)-OH provides inherent stability. This protection ensures that the tryptophan residue remains intact throughout the synthesis process, leading to higher yields and purity of the final peptide.

When you decide to purchase protected tryptophan for SPPS, choosing a reliable source for Fmoc-Trp(Boc)-OH is paramount. The compound's physical form is typically a white to off-white crystalline powder, with a melting point around 86-90°C. Its molecular formula is C31H30N2O6, and its molecular weight is 526.58. These specifications are standard for high-quality Fmoc-Trp(Boc)-OH. The application of this reagent is primarily in the Fmoc SPPS methodology, where it is coupled onto a growing peptide chain. The presence of the Boc group on the indole nitrogen is critical; it shields this reactive site until the final cleavage step, where it is efficiently removed along with other protecting groups.

The value proposition of using Fmoc-Trp(Boc)-OH, especially when sourced from an established Fmoc-L-tryptophan derivative supplier, cannot be overstated. It significantly reduces the complexity and troubleshooting required for tryptophan-containing peptides. For companies engaged in drug discovery, particularly in the development of peptide-based therapeutics, securing a consistent and high-purity supply of critical intermediates like Fmoc-Trp(Boc)-OH is a strategic imperative. As a leading Fmoc-Trp(Boc)-OH manufacturer in China, we are dedicated to meeting these demands with quality products and reliable service.

In conclusion, understanding the significance of CAS 143824-78-6, or Fmoc-Trp(Boc)-OH, is essential for anyone performing SPPS. By prioritizing quality and reliable sourcing, you can ensure the success of your peptide synthesis endeavors. We invite you to explore our offerings for this crucial reagent.