Understanding Fmoc-D-Asp-OtBu: Properties and Synthesis Applications
Fmoc-D-Asp-OtBu, identified by its CAS number 134098-70-7, is a cornerstone chemical for modern peptide synthesis, particularly within the widely adopted Fmoc solid-phase peptide synthesis (SPPS) methodology. This chiral building block, a derivative of D-aspartic acid, is characterized by the presence of the Fmoc protecting group on its alpha-amino moiety and a tert-butyl ester protecting group on its side-chain carboxyl group. Understanding the specific properties and applications of Fmoc-D-Asp-OtBu is crucial for researchers aiming to construct precise and functional peptide sequences.
The chemical structure of Fmoc-D-Asp-OtBu confers specific advantages for peptide synthesis. The Fmoc group is removed under mild basic conditions, typically using piperidine, which is orthogonal to many other protecting groups used in SPPS. This allows for selective deprotection and controlled elongation of the peptide chain. The tert-butyl ester on the aspartic acid side chain serves to prevent its participation in unwanted side reactions during the synthesis process, ensuring that the carboxyl group is available for linkage at the desired stage. As a reliable Fmoc-D-Asp-OtBu manufacturer, NINGBO INNO PHARMCHEM CO., LTD. prioritizes the synthesis of this compound with high chemical and enantiomeric purity, understanding that these factors directly impact the success of peptide assembly.
The applications for Fmoc-D-Asp-OtBu are diverse and critical in various scientific disciplines. It is extensively used in the synthesis of peptides for pharmaceutical research, including the development of peptide-based drugs, diagnostic agents, and research tools. The demand for high-quality peptide synthesis reagents means that selecting a reputable Fmoc-D-Asp-OtBu supplier is paramount. Factors such as the Fmoc-D-Asp-OtBu price, product availability, and the manufacturer's reputation for quality control are all significant considerations. NINGBO INNO PHARMCHEM CO., LTD. offers competitive Fmoc-D-Asp-OtBu price points, ensuring that researchers can access this vital component without compromising on quality.
Researchers often inquire about the synthesis process and quality assurance measures implemented by Fmoc-D-Asp-OtBu manufacturers. At NINGBO INNO PHARMCHEM CO., LTD., we are committed to transparency and excellence in our production. Our goal is to be your trusted Fmoc-D-Asp-OtBu supplier, providing you with the confidence that your peptide synthesis projects will yield accurate and reproducible results. We encourage all peptide chemists and researchers to consider our offerings for their next project requiring Fmoc-D-Asp-OtBu.
Perspectives & Insights
Chem Catalyst Pro
“The Fmoc group is removed under mild basic conditions, typically using piperidine, which is orthogonal to many other protecting groups used in SPPS.”
Agile Thinker 7
“This allows for selective deprotection and controlled elongation of the peptide chain.”
Logic Spark 24
“The tert-butyl ester on the aspartic acid side chain serves to prevent its participation in unwanted side reactions during the synthesis process, ensuring that the carboxyl group is available for linkage at the desired stage.”