The intricate world of peptide synthesis relies on specialized reagents and supports to build complex amino acid chains with precision. Among these, Fmoc-Ser(tBu)-Wang Resin stands out as a fundamental building block, particularly for incorporating the amino acid serine into peptide sequences. NINGBO INNO PHARMCHEM CO.,LTD., a dedicated manufacturer in China, understands the critical importance of this resin and provides it to researchers and industries globally.

Fmoc-Ser(tBu)-Wang Resin is a functionalized polymer bead designed for solid-phase synthesis. The resin backbone is typically cross-linked polystyrene, functionalized with a Wang linker. The key feature is the pre-attached Fmoc-protected L-serine, where the serine side chain's hydroxyl group is protected by a tert-butyl (tBu) group. This tert-butyl protection is labile under acidic conditions, allowing for efficient cleavage of the completed peptide from the resin. The Fmoc group on the alpha-amino terminus is easily removed with a mild base, facilitating the sequential addition of other Fmoc-amino acids in a controlled manner.

The utility of this resin in SPPS is significant. By starting with a pre-loaded resin, researchers can bypass the challenging initial attachment of the first amino acid to the solid support. This not only saves time but also helps ensure the purity of the synthesized peptide, as errors in the first coupling step can propagate throughout the entire synthesis. For those looking to buy Fmoc-Ser(tBu)-Wang Resin, sourcing it from a reliable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. guarantees a product with consistent loading and high purity, essential for reproducible results.

The specific characteristics of the resin, such as mesh size (e.g., 100-200 mesh) and DVB crosslinking (e.g., 1%), are optimized to balance swelling properties in common SPPS solvents with mechanical stability, ensuring efficient reagent diffusion and minimal bead attrition during synthesis. The substitution level, typically between 0.3-0.8 mmol/g, dictates the loading capacity, allowing for the synthesis of significant quantities of peptide. These technical specifications underscore why our peptide synthesis resins are a preferred choice for demanding applications.

Applications for peptides synthesized using Fmoc-Ser(tBu)-Wang Resin are vast, ranging from creating peptide libraries for drug screening to producing peptide-based vaccines and therapeutic agents. The ability to efficiently incorporate serine, a common and versatile amino acid, makes this resin a staple in peptide manufacturing. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting the advancement of peptide science by providing these essential components. When you need to buy Fmoc-Ser(tBu)-Wang Resin, consider our expertise as a leading supplier in China for your research and development needs.