In the intricate world of peptide synthesis, having the right building blocks is paramount. One such crucial component is Fmoc-Pro-OH, a derivative of the amino acid proline that plays a significant role in solid-phase peptide synthesis (SPPS). Known by its CAS number 71989-31-6, Fmoc-Pro-OH is highly sought after by researchers and pharmaceutical companies for its contribution to creating complex peptides with high purity.

The Fmoc (9-fluorenylmethoxycarbonyl) protecting group is key to the utility of Fmoc-Pro-OH. This group is stable under acidic conditions but can be readily removed by mild bases, making it ideal for the stepwise addition of amino acids in SPPS. The inclusion of proline, an imino acid with a unique cyclic structure, introduces specific conformational constraints into the resulting peptide. This can influence the peptide's biological activity, stability, and interaction with target molecules.

Exploring the Fmoc-Pro-OH chemical properties reveals its high solubility in common peptide synthesis solvents like Dimethylformamide (DMF) and N-Methyl-2-pyrrolidone (NMP), ensuring efficient reaction kinetics. The compound typically appears as a white to off-white powder, with a high purity level, often exceeding 99% as confirmed by HPLC. This level of purity is critical for obtaining successful synthesis yields and avoiding unwanted side products in complex peptide synthesis.

Beyond its primary use in SPPS, Fmoc-Pro-OH has demonstrated utility as an enzyme inhibitor, particularly targeting proteases. This action is vital in understanding enzymatic pathways and in the development of novel therapeutic agents that modulate enzyme activity. The ability to buy Fmoc-Pro-OH from reliable suppliers, such as those offering it as a key ingredient for drug discovery, underscores its importance in the pharmaceutical landscape.

For those looking to purchase Fmoc-Pro-OH, understanding the availability and pricing from different manufacturers and suppliers is essential. Whether you are looking for bulk quantities or smaller research-scale amounts, sourcing this amino acid derivative is a critical step for many ongoing scientific endeavors. The continuous demand for high-quality peptide synthesis reagents highlights the ongoing importance of Fmoc-Pro-OH in advancing scientific discovery.

In conclusion, Fmoc-Pro-OH, with its unique properties and broad applications, remains an indispensable tool for researchers in peptide synthesis and drug discovery. Its reliable performance in SPPS and its potential in therapeutic development make it a cornerstone chemical for innovation.