The Chemistry of Z-Met-OH: Properties and Applications in Organic Synthesis
The field of organic synthesis relies on a toolkit of precisely functionalized molecules to construct complex chemical structures. Among these, protected amino acids play a pivotal role, offering controlled reactivity and essential chiral building blocks. Z-Met-OH, chemically known as N-Carbobenzyloxy-L-methionine (CAS 1152-62-1), is a prime example of such a versatile compound, finding extensive use in both peptide synthesis and broader organic chemistry research.
Understanding the chemical properties of Z-Met-OH is fundamental to its effective application. It presents as a white to off-white powder, with a molecular weight of approximately 283.34 g/mol. The molecule's key feature is the N-terminal carbobenzyloxy (Z) protecting group, attached to the alpha-amino group of L-methionine. This Z group is known for its stability under various reaction conditions, including many acidic and basic treatments, and its facile removal, typically through catalytic hydrogenation, which cleaves the benzyl ester linkage.
The presence of the methionine residue provides a sulfur-containing side chain, which can engage in specific biochemical interactions or be further functionalized. In peptide synthesis, Z-Met-OH is used to introduce methionine residues into a growing peptide chain. The Z-protection prevents the alpha-amino group from reacting prematurely, ensuring regioselective peptide bond formation. This controlled reactivity is essential for constructing peptides with specific sequences and biological activities.
Beyond its indispensable role in peptide synthesis, Z-Met-OH also serves as a valuable chiral synthon in general organic synthesis. Its well-defined stereochemistry, chemical stability, and the presence of both a carboxylic acid and a protected amine group make it a flexible starting material for creating a range of organic molecules. Researchers looking to buy Z-Met-OH for these applications can rely on specialized chemical suppliers.
When seeking to purchase Z-Met-OH, particularly for research or pilot-scale synthesis, purity is a critical consideration. A high-purity Z-Met-OH (>98%) ensures that the compound reacts as expected, minimizing side products and simplifying purification procedures. Companies like NINGBO INNO PHARMCHEM CO.,LTD., a dedicated Z-Met-OH manufacturer and supplier, offer materials that meet these stringent requirements, providing researchers with confidence in their starting materials.
The versatility of Z-Met-OH makes it a sought-after compound for academic and industrial laboratories engaged in chemical research. Whether it's for developing new synthetic methodologies, exploring novel biologically active molecules, or producing high-value peptides, access to reliable, high-quality Z-Met-OH is paramount. Exploring options from a trusted Z-Met-OH manufacturer in China can provide a cost-effective and dependable source for this essential chemical building block.
Perspectives & Insights
Logic Thinker AI
“Z-Met-OH, chemically known as N-Carbobenzyloxy-L-methionine (CAS 1152-62-1), is a prime example of such a versatile compound, finding extensive use in both peptide synthesis and broader organic chemistry research.”
Molecule Spark 2025
“Understanding the chemical properties of Z-Met-OH is fundamental to its effective application.”
Alpha Pioneer 01
“It presents as a white to off-white powder, with a molecular weight of approximately 283.”