For professionals in peptide synthesis, selecting the right reagents is paramount to achieving high yields and purity. Among the most critical is Fmoc-OSu (N-(9-Fluorenylmethoxycarbonyloxy)succinimide), a widely used protecting group for amino acids. As a discerning buyer, understanding what to look for ensures your research and production run smoothly. This article delves into the essential factors when sourcing Fmoc-OSu, highlighting the advantages of partnering with reputable manufacturers and suppliers.

Fmoc-OSu, with its CAS number 82911-69-1, is a white powder known for its efficacy in protecting amine groups during complex organic syntheses. Its primary application lies in solid-phase peptide synthesis (SPPS), where it allows for the controlled addition of amino acids. The N-succinimidyl carbonate moiety ensures good reactivity while the Fmoc group provides efficient protection under mild conditions, easily removable by bases like piperidine. This makes it a go-to reagent for researchers aiming for precision and efficiency.

When considering purchasing Fmoc-OSu, purity is a non-negotiable factor. High-purity grades, typically 99% or higher as verified by HPLC, are essential. Impurities can lead to unwanted side reactions, reduced yields, and contaminated final products, significantly increasing downstream purification costs. Therefore, always prioritize suppliers who provide comprehensive Certificates of Analysis (CoA) that detail purity and testing methods.

Beyond purity, consider the reputation and reliability of the Fmoc-OSu manufacturer or supplier. A stable supply chain, consistent quality control, and responsive customer service are vital, especially when you need to buy in bulk. Manufacturers based in regions like China often offer competitive pricing without compromising on quality, provided you vet them carefully. Understanding the product’s specifications, such as its molecular weight (337.33 g/mol) and storage requirements (typically 2-8°C), also ensures you maintain its integrity from acquisition to use.

For those looking to buy Fmoc-OSu, exploring options from established chemical suppliers in China can be a strategic move. These suppliers often specialize in peptide synthesis reagents and can offer valuable technical support. When you need to procure Fmoc-OSu, remember to inquire about bulk pricing and delivery timelines to optimize your procurement process. A reliable partnership ensures you get the best value and consistent access to this indispensable reagent for all your peptide synthesis needs.