Ethyl Cyanoglyoxylate-2-Oxime (CAS 3849-21-6) is a highly versatile chemical compound that has garnered significant attention in organic synthesis, particularly within the pharmaceutical and peptide industries. Its unique structure and reactivity make it a valuable building block and auxiliary reagent. NINGBO INNO PHARMCHEM CO.,LTD. is actively involved in the supply and application of this compound, offering expert insights into its synthesis and broad utility.

The synthesis of Ethyl Cyanoglyoxylate-2-Oxime typically involves the nitrosation of ethyl cyanoacetate. This process, often carried out using sodium nitrite in the presence of an acid like acetic acid, is well-established and allows for scalable production. Careful control of reaction parameters, such as temperature and reagent addition rates, is crucial to ensure high yield and purity. The resulting product, a pale yellow to almost white crystalline powder, is then purified to meet stringent quality requirements, often exceeding 99% purity as determined by HPLC. For manufacturers looking to buy this chemical, understanding the synthesis process provides confidence in its quality.

The primary application for Ethyl Cyanoglyoxylate-2-Oxime that has driven its demand is its role as a peptide coupling reagent. It serves as a highly effective and safer alternative to traditional reagents like HOBt, offering superior performance in terms of reaction speed and the reduction of chiral racemization. This makes it indispensable for the synthesis of peptides and peptide-based APIs, where maintaining stereochemical integrity is paramount.

Beyond peptide synthesis, Ethyl Cyanoglyoxylate-2-Oxime finds utility in various other areas of organic synthesis. Its reactive functional groups – the ester, nitrile, and oxime moieties – allow it to participate in a wide range of chemical transformations. It can be used in the synthesis of heterocyclic compounds, as well as in the formation of various functional groups essential for creating complex organic molecules. As a supplier, NINGBO INNO PHARMCHEM CO.,LTD. sees its application growing in the development of novel pharmaceuticals, agrochemicals, and specialty chemicals.

The combined advantages of its efficient synthesis, superior performance in key applications like peptide coupling, and its potential for broader use in organic synthesis solidify Ethyl Cyanoglyoxylate-2-Oxime's position as a valuable chemical building block. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality Ethyl Cyanoglyoxylate-2-Oxime to support the innovative work of chemists worldwide, contributing to advancements in drug discovery and chemical manufacturing.