For chemists and researchers involved in agrochemical synthesis, a thorough understanding of the chemical profile of key intermediates is essential. This article provides a detailed overview of 3,6-Dihydro-3-methyl-N-nitro-2H-1,3,5-oxadiazin-4-amine (CAS 153719-38-1), a critical intermediate for the production of Thiamethoxam. We will explore its molecular structure, physical properties, and safety considerations, offering insights valuable for R&D scientists and process engineers.

Chemical Structure and Properties

3,6-Dihydro-3-methyl-N-nitro-2H-1,3,5-oxadiazin-4-amine is a heterocyclic organic compound with the molecular formula C₄H₈N₄O₃. Its molecular weight is approximately 160.13 g/mol. The core structure features a six-membered ring containing two oxygen atoms and three nitrogen atoms (a 1,3,5-oxadiazine ring), with a methyl group attached to one nitrogen and a nitro group linked to another nitrogen via an imine functional group. This specific arrangement of atoms and functional groups dictates its reactivity and suitability as a precursor in complex chemical syntheses.

Key physical and chemical properties include:

  • Appearance: Typically presented as a white to off-white solid or crystalline powder.
  • Melting Point: Reported to be in the range of 141-143°C, indicating a stable solid form at room temperature.
  • Solubility: Exhibits slight solubility in heated chloroform and methanol, suggesting moderate polarity.
  • Stability: It is noted to be light-sensitive, necessitating storage in amber vials and protection from direct light.
  • Assay: High purity grades, such as 99% or higher, are generally available to ensure optimal performance in synthesis.

Synthesis and Handling Considerations

The synthesis of 3,6-Dihydro-3-methyl-N-nitro-2H-1,3,5-oxadiazin-4-amine often involves reactions between nitroguanidine derivatives and formaldehyde or related compounds. Industrial synthesis pathways are optimized for yield and purity. When handling this compound, standard laboratory safety practices should be observed. Due to the presence of the nitro group and its classification as a harmful substance if swallowed (H302), appropriate personal protective equipment (PPE) such as gloves, eye protection, and lab coats should be worn. Adequate ventilation is also recommended to prevent inhalation of dust. It is important to consult the Material Safety Data Sheet (MSDS) for comprehensive safety information and handling guidelines.

Application in Agrochemicals

The primary application of this compound is as a critical intermediate in the manufacturing of Thiamethoxam, a neonicotinoid insecticide. Its unique chemical structure provides the necessary functional groups and backbone for building the Thiamethoxam molecule. As a reliable supplier of high-purity 3,6-Dihydro-3-methyl-N-nitro-2H-1,3,5-oxadiazin-4-amine from China, we are committed to providing researchers and manufacturers with the quality materials they need for successful agrochemical development. If you require this intermediate for your research or production, please contact us for a quote or more detailed technical specifications.