The Chemical Properties and Applications of 2-Chloro-5-trifluoromethylpyridine
In the dynamic world of chemical manufacturing, understanding the intrinsic properties and versatile applications of key intermediates is crucial for innovation and product development. 2-Chloro-5-trifluoromethylpyridine (CAS: 52334-81-3) is one such compound, recognized for its significant role in both the agrochemical and pharmaceutical industries. As a prominent supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing this high-value intermediate, along with a deep understanding of its chemical characteristics.
The molecular structure of 2-Chloro-5-trifluoromethylpyridine is key to its utility. It features a pyridine ring, a six-membered aromatic heterocycle containing nitrogen. This ring is substituted at the 2-position with a chlorine atom and at the 5-position with a trifluoromethyl group (-CF3). The chlorine atom serves as a reactive handle for various synthetic transformations, including nucleophilic substitution and palladium-catalyzed cross-coupling reactions. The trifluoromethyl group, a strongly electron-withdrawing substituent, significantly influences the electronic distribution within the pyridine ring. This influence can enhance lipophilicity, increase metabolic stability, and modify the binding affinity of molecules derived from this intermediate, which are highly desirable traits in both pharmaceuticals and agrochemicals.
The physical properties of 2-Chloro-5-trifluoromethylpyridine are also noteworthy. Typically appearing as a colorless or light yellow transparent liquid or crystal, it has a melting point around 32-34°C and a boiling point of approximately 171.6°C at atmospheric pressure. These characteristics make it amenable to standard chemical processing and purification techniques.
The applications of this compound are broad and impactful. In the agrochemical sector, it is primarily used as an intermediate for the synthesis of herbicides, contributing to more effective crop protection strategies and increased agricultural yields. For the pharmaceutical industry, it acts as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs). The incorporation of the trifluoromethylpyridine moiety can lead to drug candidates with improved bioavailability, efficacy, and pharmacokinetic profiles. Beyond these major sectors, research also explores its potential utility in material science due to its unique electronic properties.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying 2-Chloro-5-trifluoromethylpyridine with the highest standards of purity and consistency. Our expertise in chemical synthesis ensures that our clients receive a reliable product that meets their demanding specifications. By understanding the chemical properties and application potential of this vital intermediate, we aim to be a key partner in the innovation and success of our clients across various industries, supporting advancements in agriculture and medicine through the power of chemistry.
The molecular structure of 2-Chloro-5-trifluoromethylpyridine is key to its utility. It features a pyridine ring, a six-membered aromatic heterocycle containing nitrogen. This ring is substituted at the 2-position with a chlorine atom and at the 5-position with a trifluoromethyl group (-CF3). The chlorine atom serves as a reactive handle for various synthetic transformations, including nucleophilic substitution and palladium-catalyzed cross-coupling reactions. The trifluoromethyl group, a strongly electron-withdrawing substituent, significantly influences the electronic distribution within the pyridine ring. This influence can enhance lipophilicity, increase metabolic stability, and modify the binding affinity of molecules derived from this intermediate, which are highly desirable traits in both pharmaceuticals and agrochemicals.
The physical properties of 2-Chloro-5-trifluoromethylpyridine are also noteworthy. Typically appearing as a colorless or light yellow transparent liquid or crystal, it has a melting point around 32-34°C and a boiling point of approximately 171.6°C at atmospheric pressure. These characteristics make it amenable to standard chemical processing and purification techniques.
The applications of this compound are broad and impactful. In the agrochemical sector, it is primarily used as an intermediate for the synthesis of herbicides, contributing to more effective crop protection strategies and increased agricultural yields. For the pharmaceutical industry, it acts as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs). The incorporation of the trifluoromethylpyridine moiety can lead to drug candidates with improved bioavailability, efficacy, and pharmacokinetic profiles. Beyond these major sectors, research also explores its potential utility in material science due to its unique electronic properties.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying 2-Chloro-5-trifluoromethylpyridine with the highest standards of purity and consistency. Our expertise in chemical synthesis ensures that our clients receive a reliable product that meets their demanding specifications. By understanding the chemical properties and application potential of this vital intermediate, we aim to be a key partner in the innovation and success of our clients across various industries, supporting advancements in agriculture and medicine through the power of chemistry.
Perspectives & Insights
Logic Thinker AI
“2-Chloro-5-trifluoromethylpyridine (CAS: 52334-81-3) is one such compound, recognized for its significant role in both the agrochemical and pharmaceutical industries.”
Molecule Spark 2025
“is dedicated to providing this high-value intermediate, along with a deep understanding of its chemical characteristics.”
Alpha Pioneer 01
“The molecular structure of 2-Chloro-5-trifluoromethylpyridine is key to its utility.”