In the realm of chemical synthesis, understanding the intricate properties of intermediates is paramount for safe and effective use. 2-Chloro-1-methoxypropane (CAS 5390-71-6) is a chemical intermediate valued for its role in agrochemical production, particularly as a precursor to Metolachlor. This article delves into its key chemical properties, specifications, and essential handling guidelines for professionals in the field.

Chemical Identity and Basic Properties

2-Chloro-1-methoxypropane is an organochlorine compound and an ether, with the molecular formula C4H9ClO and a molecular weight of approximately 108.57 g/mol. It is commonly supplied as a clear, colorless liquid. The presence of both a chloroalkyl group and a methoxy ether group imparts specific reactivity, making it a versatile intermediate in organic synthesis.

Key physical and chemical properties include:

  • Boiling Point: Estimated around 122.94°C.
  • Density: Approximately 0.9946 g/cm³.
  • Refractive Index: Around 1.4075.
  • LogP: Approximately 1.1, indicating moderate lipophilicity.
  • Topological Polar Surface Area (PSA): About 9.2 Ų, suggesting relatively low polarity.

These properties influence its behavior during reactions, solubility, and separation processes.

Critical Specifications for Industrial Use

For manufacturers and formulators, adhering to stringent specifications is crucial for ensuring product quality and process efficiency. The standard specifications for 2-Chloro-1-methoxypropane typically include:

  • Assay Purity: A high purity level of ≥99.0% is essential for precise chemical reactions, minimizing byproducts, and ensuring the efficacy of downstream products like Metolachlor.
  • Loss on Drying: A limit of ≤0.5% for loss on drying signifies low moisture content, contributing to the compound’s stability and shelf-life.
  • Appearance: Supplied as a clear liquid, this visual cue helps in initial quality assessment.

These specifications are vital for purchasers to verify when sourcing from suppliers. Companies like NINGBO INNO PHARMCHEM CO.,LTD. emphasize these quality metrics to assure customers of reliable material performance.

Applications and Reactivity

The primary industrial application of 2-Chloro-1-methoxypropane is as a pivotal intermediate in the synthesis of Metolachlor, a widely used herbicide. Its chemical structure allows it to undergo nucleophilic substitution reactions, where the chlorine atom can be replaced, and reactions involving the ether functionality. This reactivity makes it a valuable building block for creating complex molecules essential for crop protection.

Its potential extends to other areas of organic synthesis where its specific functional groups can be leveraged to create novel compounds. For researchers, understanding its reactivity patterns with various reagents is key to exploring new synthetic pathways.

Handling and Storage Guidelines

Proper handling and storage are crucial for maintaining the quality and safety of 2-Chloro-1-methoxypropane:

  • Storage Conditions: Store in a cool, dry, and well-ventilated place to prevent degradation. Containers should be kept tightly closed.
  • Handling Precautions: As with many organic chemicals, it is advisable to handle it in a well-ventilated area or under a fume hood. Avoid contact with skin, eyes, and clothing. Wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and protective clothing.
  • Incompatibilities: Keep away from strong oxidizing agents and strong acids.

By adhering to these guidelines, users can ensure the safe and effective use of 2-Chloro-1-methoxypropane in their manufacturing processes.

Conclusion

2-Chloro-1-methoxypropane is a cornerstone intermediate for the agrochemical industry, particularly for herbicide production. Its well-defined chemical properties, combined with stringent quality specifications, make it a reliable building block for manufacturers. Understanding these properties and following proper handling procedures ensures its effective and safe utilization, supporting the production of vital agricultural products.