The chemical industry thrives on the precise manipulation of molecules to create compounds with desired properties and applications. For specialists in organic synthesis, understanding the reactivity and synthesis pathways of key intermediates is fundamental. 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid (CAS: 500011-86-9) is a prime example of such a compound, whose specific functional groups dictate its synthetic utility, particularly in the agrochemical sector. As a dedicated manufacturer, we offer insights into its chemical nature and production.

The molecular structure of 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid is rich in reactive sites. The carboxylic acid group (-COOH) is a versatile functional handle, readily undergoing esterification, amidation, or conversion to acyl halides. This allows for its facile coupling with various amines, a critical step in the synthesis of insecticides like Chlorantraniliprole, where it reacts with anthranilic acid derivatives. The bromine atom at the pyrazole ring can participate in substitution reactions or cross-coupling methodologies, such as Suzuki or Stille couplings, enabling the introduction of diverse substituents. The chloropyridinyl group also offers potential for further chemical transformations.

The synthesis of this compound typically involves a sequence that builds the pyrazole ring and introduces the necessary substituents. Common routes often start with substituted pyridines and pyrazole precursors, employing reactions like hydrazinolysis, cyclization, and halogenation. For instance, a common pathway involves the synthesis of ethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate, followed by the hydrolysis of the ester to the carboxylic acid. The efficiency of these steps, including the choice of reagents (e.g., using potassium persulfate for dehydrogenation or sodium hydroxide for hydrolysis) and reaction conditions, is crucial for achieving high yields and purity, often above 98%. If you are seeking to buy 3-bromo-1-(3-chloro-2-pyridinyl)-1h-pyrazole-5-carboxylic acid, understanding these synthesis nuances helps appreciate the quality offered by reliable manufacturers.

The reactivity of the carboxylic acid moiety makes it an ideal point for chain extension or modification. Its conversion to an acyl chloride, for example, creates a highly electrophilic intermediate that readily reacts with nucleophiles. This reactivity profile is what makes it indispensable for forming the amide bonds characteristic of many modern pesticides. Furthermore, the specific arrangement of the bromine atom and the chloropyridinyl group on the pyrazole ring has been shown to enhance the binding affinity of the resulting insecticides to their target sites, such as insect ryanodine receptors, ensuring potent and selective action. For researchers exploring new derivatives, this compound serves as an excellent starting point.

As a premier CAS 500011-86-9 supplier, we ensure that our product is synthesized under rigorous conditions, yielding a high-purity intermediate ready for your downstream applications. Whether your interest lies in agrochemical formulation, pharmaceutical research, or the synthesis of other fine chemicals, our consistent supply and quality assurance are designed to support your innovative endeavors. We invite you to connect with us to learn more about the chemical properties and applications of this versatile intermediate, and to secure a reliable supply for your laboratory or production facility.