At NINGBO INNO PHARMCHEM CO., LTD., we are committed to providing comprehensive information on our high-quality chemical products. Polyvinylpyrrolidone K90 (PVP K90) is a versatile polymer with a remarkable solubility profile, making it a key ingredient in numerous applications across chemical and pharmaceutical sectors. Understanding its solubility characteristics is crucial for effective formulation development.

PVP K90 is known for its excellent solubility in water and a wide range of organic solvents. This broad solubility spectrum stems from the polar nature of its amide group, which allows it to form hydrogen bonds with polar solvent molecules. Consequently, PVP K90 readily dissolves in:

  • Water: This is its primary solvent, forming clear, colorless to slightly yellowish solutions.
  • Alcohols: Such as methanol, ethanol, and isopropyl alcohol.
  • Carboxylic Acids: Including formic acid and acetic acid.
  • Halogenated Hydrocarbons: Like dichloromethane and chloroform.
  • Other Polar Organic Solvents: Including glycols, amines, and lactones.

This extensive solubility makes PVP K90 an ideal candidate for various formulation needs. In the pharmaceutical industry, its use as a dissolution enhancer relies heavily on its ability to solubilize poorly water-soluble drugs. By forming complexes or solid dispersions, PVP K90 significantly increases the effective solubility and dissolution rate of APIs, leading to improved bioavailability.

The solubility of PVP K90 is also influenced by its molecular weight, with higher K-values generally indicating higher viscosity but similar solubility characteristics in many solvents. Its hygroscopic nature means it can absorb moisture from the air, which can affect its handling and solution properties if not stored properly.

For chemical formulators, the compatibility of PVP K90 with diverse solvents opens up possibilities in coatings, adhesives, and specialty chemicals. Its film-forming, complexing, and stabilizing properties, combined with its solubility, make it a valuable additive. For instance, in inks and coatings, PVP K90 can act as a dispersant and stabilizer for pigments, ensuring uniformity and preventing agglomeration.

NINGBO INNO PHARMCHEM CO., LTD. provides high-purity PVP K90 that meets rigorous quality standards, ensuring predictable performance in all applications. Whether you are developing advanced pharmaceutical formulations or innovative chemical products, understanding the PVP K90 solubility is key to successful product development.