The intricate relationship between small molecules and DNA is a cornerstone of molecular biology and pharmaceutical research. Among the myriad of compounds used to probe and interact with genetic material, 1,10-Phenanthroline Monohydrochloride (CAS: 3829-86-5) has garnered significant attention for its ability to act as a DNA intercalator.

Understanding DNA Intercalation

DNA intercalation refers to the process where planar molecules insert themselves between the base pairs of the DNA double helix. This insertion can distort the DNA structure, affecting processes like replication and transcription. Metal complexes formed with planar ligands like phenanthroline are particularly effective at this, often exhibiting specific binding preferences and enantioselectivity.

The Role of 1,10-Phenanthroline Monohydrochloride

1,10-Phenanthroline Monohydrochloride, as a key heterocyclic intermediate, provides the foundational structure for creating potent metallointercalators. Its rigid, aromatic system allows it to slip between DNA base pairs. When coordinated with transition metals (such as Ruthenium or Platinum), these phenanthroline-based complexes can exhibit:

  • Specific DNA Binding: Targeted interaction with the DNA helix, often with a preference for certain sequences or structures.
  • Enantioselective Recognition: Preferential binding to one enantiomer of a chiral complex, leading to distinct biological and optical properties.
  • Modulation of Biological Activity: The ability to inhibit enzymes involved in DNA metabolism or to induce DNA damage, making them candidates for anticancer therapeutics.
  • Fluorescent Properties: Many such complexes display unique fluorescence characteristics upon binding to DNA, enabling their use as probes in bioimaging and analytical assays.

Sourcing for Bioinorganic Research

Researchers engaged in bioinorganic chemistry and the study of DNA-metal interactions require a reliable supply of high-purity 1,10-Phenanthroline Monohydrochloride. As a leading chemical manufacturer and supplier based in China, we are committed to providing the quality and consistency essential for this sensitive research. Our product, with its guaranteed purity, serves as an indispensable starting material for synthesizing these complex bio-active agents.

When you need to purchase this crucial chemical intermediate, choosing a trusted supplier ensures that your experiments are built on a foundation of quality. We offer competitive pricing and dedicated support, enabling scientists to advance their research into DNA-metal interactions and their therapeutic potential. Partner with us to procure the high-quality ligands needed for your groundbreaking work.