In the realm of pharmaceutical synthesis, precision and purity are non-negotiable. 1-Aminoindan (CAS 34698-41-4) is a prime example of a chemical compound whose technical specifications directly dictate its utility and value. This article provides an in-depth look at the technical aspects of 1-Aminoindan, with a particular focus on its indispensable role in the synthesis of Rasagiline Mesylate. For R&D scientists and formulation chemists, understanding these details is crucial for successful application and procurement.

Key Technical Specifications of 1-Aminoindan

1-Aminoindan, with the molecular formula C9H11N and a molecular weight of approximately 133.19 g/mol, is characterized by several critical technical specifications:

  • Appearance: Typically a colorless to light yellow liquid. This visual characteristic is an initial indicator of quality and stability.
  • Assay (Purity): A minimum purity of ≥99.0% is standard for pharmaceutical applications. This high assay ensures minimal impurities that could interfere with downstream reactions or affect the final API's profile.
  • CAS Number: 34698-41-4 is the unique identifier, essential for accurate ordering and regulatory compliance.
  • Physical Properties: Density (approx. 1.1 g/cm³) and boiling point (around 225.0 °C at 760 mmHg) are important for chemical engineers and formulators when designing reaction conditions and processes.
  • Storage: It is recommended to store 1-Aminoindan in a cool, ventilated place to maintain its quality and shelf life.

The Critical Application: Synthesis of Rasagiline Mesylate

The most significant application of 1-Aminoindan lies in its function as a key intermediate for the synthesis of Rasagiline Mesylate (CAS 161735-79-1). Rasagiline is a potent and selective irreversible inhibitor of monoamine oxidase B (MAO-B), used clinically to manage the symptoms of Parkinson's disease. The synthesis of Rasagiline involves specific chemical transformations where 1-Aminoindan provides the core structural element. Ensuring a consistent supply of high-purity 1-Aminoindan is therefore paramount for manufacturers of this crucial medication.

Procurement Considerations for Technical Purity

When procuring 1-Aminoindan, R&D scientists and procurement specialists must prioritize suppliers who can consistently meet these technical specifications. Working with a reputable manufacturer, such as those offering this compound from China, is often the best way to secure high-purity material at competitive prices. It is vital to obtain a Certificate of Analysis (COA) with each batch to verify its compliance with the stated technical details. Understanding these specifications allows for informed decisions when selecting a supplier and ensuring the success of your synthetic processes.

For any organization looking to purchase 1-Aminoindan for pharmaceutical development or manufacturing, a thorough understanding of its technical data, coupled with a commitment to sourcing from trusted manufacturers, is essential. This ensures the integrity of your research and production, ultimately contributing to the availability of critical medicines.