In the vast landscape of organic chemistry, specific molecules stand out for their pivotal roles in industrial synthesis. 1-Benzyl-4-piperidinecarboxaldehyde (CAS 22065-85-6) is one such compound, recognized for its utility as a critical intermediate, particularly within the pharmaceutical sector. This article delves into its synthesis, key properties, and the diverse applications that make it a sought-after chemical.

Synthesis and Manufacturing Insights

The production of 1-Benzyl-4-piperidinecarboxaldehyde involves precise chemical reactions, often starting from readily available precursors. While specific proprietary methods vary among manufacturers, the general approach often involves the selective oxidation of a related alcohol or the functionalization of a piperidine core. Companies that specialize in fine chemical manufacturing, especially those based in China, have developed efficient and scalable processes to produce this intermediate. These manufacturing efforts are crucial for meeting the global demand, ensuring consistent quality and availability for pharmaceutical and chemical industries.

Key Physical and Chemical Properties

1-Benzyl-4-piperidinecarboxaldehyde (C13H17NO, MW: 203.28) is typically supplied as a colorless oil. Its physical characteristics, such as density and boiling point, are well-documented, providing essential data for process engineers and chemists. For instance, its boiling point of 315.4 °C at 760 mmHg indicates its relative stability under high-temperature conditions often encountered in chemical synthesis. The compound’s chemical structure, featuring both an aldehyde group and a protected amine functionality, allows it to participate in a wide range of reactions, including Wittig reactions, Grignard additions, and reductive aminations, making it a versatile synthon.

Primary Applications and Market Demand

The most prominent application of 1-Benzyl-4-piperidinecarboxaldehyde is its role as a key intermediate in the synthesis of Donepezil hydrochloride, a vital drug for Alzheimer's disease. Beyond this, its chemical reactivity makes it valuable in the development of other pharmaceutical agents and as a building block in complex organic synthesis projects. Researchers and chemists often look to purchase this intermediate to explore novel molecular architectures and create libraries of compounds for drug screening. The consistent demand from the pharmaceutical industry, driven by the need for effective treatments for neurological disorders, ensures a steady market for this essential chemical.

Choosing the Right Supplier

When selecting a supplier for 1-Benzyl-4-piperidinecarboxaldehyde, consider factors such as purity (often specified as 95% or 98% by GC), packaging options (e.g., drums for bulk orders), and reliable delivery schedules. Manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., are well-equipped to meet these requirements, offering high-quality products at competitive prices. If you are looking to buy this intermediate for your synthesis needs, reaching out to experienced chemical manufacturers will ensure you obtain material that meets your exact specifications. Partner with us for your chemical sourcing requirements and benefit from our expertise.