For chemists and material scientists, understanding the properties and applications of key chemical building blocks is fundamental to innovation. 1-Bromo-3,5-dimethoxybenzene (CAS 20469-65-2) is one such compound that has garnered significant attention due to its versatility in organic synthesis, particularly as a pharmaceutical intermediate. Whether you are looking to buy 1-Bromo-3,5-dimethoxybenzene for research or industrial processes, understanding its chemical profile is paramount.

1-Bromo-3,5-dimethoxybenzene is characterized by its molecular formula C8H9BrO2 and a molecular weight of 217.06 g/mol. It typically presents as a white to light pink crystalline powder, with a melting point in the range of 62-66°C. Its density is approximately 1.412 g/cm³, and it is soluble in common organic solvents like methanol. The presence of the bromine atom and the two methoxy groups on the benzene ring imparts specific reactivity, making it a prime candidate for various synthetic transformations.

The primary utility of this compound lies in its role as an intermediate for constructing more complex organic molecules. Its bromine substituent makes it highly reactive in palladium-catalyzed cross-coupling reactions. These reactions are indispensable in modern synthetic chemistry for forging carbon-carbon bonds, a crucial step in the creation of many pharmaceuticals, agrochemicals, and advanced materials. For instance, it readily participates in Suzuki, Stille, and Sonogashira couplings, enabling chemists to introduce diverse functional groups onto the aromatic core.

As a pharmaceutical intermediate, 1-Bromo-3,5-dimethoxybenzene is used in the synthesis of drug candidates, including potential pharmaceutical inhibitors. Its structure allows for precise functionalization, which is critical in medicinal chemistry for optimizing drug efficacy and pharmacokinetic properties. The ability to reliably purchase this compound from a reputable manufacturer ensures that researchers and production teams have access to a consistent and high-quality supply.

When selecting a 1-Bromo-3,5-dimethoxybenzene supplier, buyers should prioritize those who can guarantee high purity (≥98.0%) and provide detailed technical documentation. Many international companies source this intermediate from China, where a robust chemical manufacturing sector offers competitive price points and large-scale production capabilities. However, thorough vetting of suppliers is essential to ensure product quality and a stable supply chain.

In summary, 1-Bromo-3,5-dimethoxybenzene is a cornerstone compound for chemists involved in advanced organic synthesis. Its well-defined chemical properties and participation in crucial cross-coupling reactions make it an invaluable pharmaceutical intermediate. By understanding its characteristics and choosing the right manufacturer or supplier, organizations can effectively leverage this compound to drive their research and production forward.