For research and development scientists and chemists, a deep understanding of the chemical properties and reactivity of intermediates like 1-Bromo-4-Fluorobenzene (CAS 460-00-4) is fundamental to successful synthesis. This compound, a halogenated aromatic, offers a unique combination of a bromine atom and a fluorine atom on a benzene ring, positioning it as a versatile building block in various chemical transformations.

Chemically, 1-Bromo-4-Fluorobenzene exists as a solid at room temperature, with a melting point of -16°C, indicating it is typically handled as a solid. Its boiling point is approximately 154.5°C at 760 mmHg. The presence of both bromine and fluorine atoms influences its reactivity. The bromine atom is particularly susceptible to nucleophilic substitution and is often the reactive site in Grignard reagent formation. This is a critical aspect for chemists looking to introduce the 4-fluorophenyl group into target molecules. For instance, reacting 1-Bromo-4-Fluorobenzene with magnesium metal in an anhydrous ether solvent yields the corresponding Grignard reagent, a powerful nucleophile widely used in carbon-carbon bond formation.

Beyond Grignard chemistry, 1-Bromo-4-Fluorobenzene is a standard substrate for various palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. These reactions are indispensable tools in modern organic synthesis for constructing complex molecular architectures found in pharmaceuticals and advanced materials. Researchers can reliably buy this intermediate from reputable chemical suppliers to explore these synthetic pathways.

The compound's utility extends to its application as a pharmaceutical intermediate, where it acts as a precursor for the synthesis of active pharmaceutical ingredients (APIs). Its fluorine substituent can impart favorable pharmacokinetic properties to drug candidates, such as increased metabolic stability or altered lipophilicity. Similarly, in agrochemical production, it contributes to the development of new pesticides and herbicides.

For scientists aiming to purchase 1-Bromo-4-Fluorobenzene, seeking a manufacturer that provides detailed specifications, including purity analysis (e.g., by HPLC), and reliable technical data is crucial. Availability from trusted chemical suppliers ensures that your research is not hampered by inconsistent quality. When you buy this product, inquire about its handling and storage recommendations to maintain its integrity. Exploring the synthesis of complex molecules with high-purity 1-Bromo-4-Fluorobenzene, sourced from a dependable manufacturer in China, can significantly streamline your R&D process.