For research and development scientists, the selection of high-quality, precisely characterized chemical intermediates is fundamental to the success of their experiments and the development of new compounds. 1-Bromo-4-fluorobutane (CAS 462-72-6) is a molecule that consistently proves its value in synthetic organic chemistry due to its bifunctional nature. This article aims to provide R&D scientists with a comprehensive overview of this compound, from its physical properties to its broad synthetic applications, emphasizing the critical aspect of sourcing reliable material.

Understanding the Chemical Profile
1-Bromo-4-fluorobutane is a colorless liquid with a molecular formula of C4H8BrF and a molecular weight of approximately 155.01 g/mol. Key physical properties that are essential for R&D planning include its boiling point, typically cited between 134-135°C, a density of around 1.444 g/mL at 25°C, and a refractive index of n20/D 1.439. These parameters are crucial for reaction setup, purification strategies, and analytical characterization. Its solubility characteristics, often sparingly soluble in water, dictate suitable solvent choices for reactions and work-ups.

Synthetic Utility: A Chemist's Toolkit
The true strength of 1-bromo-4-fluorobutane lies in its reactivity. The presence of two different halogens on opposite ends of the alkane chain allows for sequential functionalization. Chemists can leverage the more reactive carbon-bromine bond for nucleophilic substitutions, forming new carbon-carbon, carbon-nitrogen, or carbon-oxygen bonds. This is particularly useful for introducing the 4-fluorobutyl chain into larger molecules, such as drug candidates or functional materials. For instance, it can be used to alkylate amines to form fluorinated amine derivatives, or react with organometallic reagents to extend carbon chains. The fluorine atom, being less reactive, can be retained in the final product to impart specific electronic or physiochemical properties, such as altered pKa, increased lipophilicity, or enhanced metabolic stability.

Ensuring Quality for Research Success
In R&D settings, even minor impurities can lead to unexpected outcomes or invalidate experimental data. Therefore, it is imperative to buy 1-bromo-4-fluorobutane from a trusted supplier that guarantees high purity and batch-to-batch consistency. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing research-grade chemicals with detailed specifications and analytical data. When sourcing this intermediate, always look for suppliers who provide a Certificate of Analysis confirming the purity (typically >95%, often >97% or >98%) and identity of the compound. This diligence in sourcing ensures that your research efforts are built upon a foundation of reliable chemical inputs.

Partnering for Innovation
As you plan your next synthetic endeavor, consider the strategic advantage of partnering with an established chemical supplier. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer and supplier in China, offers high-quality 1-Bromo-4-fluorobutane to support your critical R&D projects. We encourage you to reach out to us for product information, pricing, and to discuss your specific project requirements.