In the intricate world of pharmaceutical research and development, access to specialized chemical building blocks is fundamental. 1-Bromo-4-iodobenzene (CAS: 589-87-7) emerges as a highly valuable intermediate, offering unique reactivity and structural features that are indispensable for modern drug discovery and synthesis. For procurement managers and research scientists, understanding its utility and securing a dependable supply chain is crucial.

The Chemical Profile of 1-Bromo-4-iodobenzene

1-Bromo-4-iodobenzene is characterized by its dual halogen substituents—bromine and iodine—attached to a benzene ring in a para configuration. This specific arrangement (C6H4BrI) imparts distinct chemical properties, including selective reactivity at either halogen site. Typically presented as a white to brown crystalline powder or needles, it boasts a high purity level, often exceeding 97% or 98%. Its molecular weight is approximately 282.90 g/mol, with a melting point in the range of 89-93°C, indicating a solid form at standard room temperatures. The compound's insolubility in water but solubility in various organic solvents further enhances its utility in diverse synthetic procedures.

Significance in Pharmaceutical Synthesis and Drug Discovery

The pharmaceutical industry leverages 1-Bromo-4-iodobenzene extensively due to its potential in creating biologically active molecules. Its halogen atoms serve as reactive handles that can be selectively modified through various chemical reactions, including palladium-catalyzed cross-coupling reactions like Suzuki-Miyaura and Stille couplings. These reactions are critical for constructing complex carbon-carbon bonds, enabling the synthesis of intricate molecular architectures that are often the basis for novel drug candidates. Researchers utilize this intermediate to introduce specific functionalities, influence molecular properties such as lipophilicity and metabolic stability, and ultimately fine-tune the pharmacological activity and pharmacokinetic profiles of potential therapeutics.

Its application extends to the synthesis of alkaloids, such as ent-conduramine A and ent-7-deoxypancratistatin, demonstrating its role in creating complex natural product analogs with therapeutic potential. Furthermore, its use in preparing di-substituted styrenes showcases its versatility in generating various organic scaffolds relevant to medicinal chemistry.

Strategic Sourcing for Pharmaceutical R&D

For organizations looking to purchase 1-Bromo-4-iodobenzene, finding a reliable manufacturer or supplier is a top priority. Key considerations include ensuring high purity (97% Min.) to guarantee consistent results in sensitive synthetic steps, competitive pricing for efficient budgeting, and a stable supply chain to support ongoing research and development programs. Sourcing from reputable companies, especially those with a strong presence in China, can provide access to quality materials at advantageous costs. It is often beneficial for R&D teams to request a free sample to validate the product's suitability for their specific applications before committing to larger orders. The ability to obtain a quote for bulk quantities is also a standard requirement for pharmaceutical companies scaling up synthesis.

In summary, 1-Bromo-4-iodobenzene is an indispensable intermediate for the pharmaceutical sector, offering a unique combination of structural features and reactivity. By strategically sourcing this compound from experienced chemical suppliers, researchers and procurement specialists can ensure the efficient development and production of next-generation medicines.