In the vast landscape of organic chemistry, certain compounds stand out due to their critical roles as building blocks for more complex molecules. 1-Chloromethyl Naphthalene, identified by its CAS number 86-52-2, is one such compound. This article delves into its essential properties, diverse applications, and practical considerations for sourcing this valuable chemical intermediate.

1-Chloromethyl Naphthalene (C11H9Cl) is a halogenated aromatic hydrocarbon derived from naphthalene. Its molecular structure features a chloromethyl group (-CH2Cl) attached to the naphthalene ring at the alpha (1) position. This reactive functional group makes it a highly versatile reagent in synthetic chemistry. The typical assay for this compound is around 99%, ensuring high purity suitable for demanding applications.

The physical characteristics of 1-Chloromethyl Naphthalene can vary. It is often described as a colorless crystal or liquid, depending on its exact form and ambient temperature. Its melting point is around 32°C, and its boiling point is approximately 291°C. It is generally insoluble in water but soluble in organic solvents like chloroform and ethyl acetate. When considering its use, understanding its stability and storage conditions is important. It is typically stored in a cool, dry place, away from direct sunlight to maintain its integrity.

The applications of 1-Chloromethyl Naphthalene are primarily centered around its utility as a synthetic intermediate. It is a key component in the production of various pharmaceutical compounds, acting as a precursor for numerous active pharmaceutical ingredients (APIs). The chloromethyl group allows for straightforward derivatization, enabling chemists to build complex molecular structures required for therapeutic agents. Beyond pharmaceuticals, it is also employed in the synthesis of specialized resins, where its structure can impart desirable material properties. Some sources also indicate its use in the synthesis of dyes and pigments.

For businesses looking to purchase 1-Chloromethyl Naphthalene, several considerations are paramount. The purity of the compound is often the most critical factor, especially for pharmaceutical use. Therefore, selecting a supplier that guarantees a high assay (e.g., 99% min) is essential. Understanding the typical specifications provided by manufacturers, such as limits for chloride, ammonium, sulfate, iron, and heavy metals, can help in selecting the right grade. Furthermore, ensuring a stable supply chain is vital for continuous production.

When searching for a reliable supplier of 1-Chloromethyl Naphthalene, manufacturers and distributors in major chemical production regions are often the first point of contact. China, in particular, is a significant global hub for chemical manufacturing, offering a wide range of intermediates at competitive prices. Procurement managers should actively seek out suppliers who can provide Certificates of Analysis (CoA) and Safety Data Sheets (SDS) readily. Inquiring about pricing for different quantities, from research-scale samples to bulk industrial orders, is also a standard practice. Many suppliers offer online platforms where one can request a quote or view product details and pricing.

In summary, 1-Chloromethyl Naphthalene (CAS 86-52-2) is a valuable and versatile chemical intermediate with significant applications in pharmaceuticals and beyond. Its high purity and reactive nature make it a cornerstone for many synthetic pathways. By carefully evaluating its properties and partnering with reputable manufacturers and suppliers, researchers and industrial chemists can effectively leverage this compound for their innovative projects.