The pharmaceutical industry relies heavily on a steady supply of precisely manufactured chemical intermediates to develop life-saving and life-enhancing drugs. Among these crucial compounds, 1-Fluoro-2-nitrobenzene (CAS 1493-27-2) plays a significant role. Its unique chemical structure makes it a versatile building block in the synthesis of a wide range of active pharmaceutical ingredients (APIs). For researchers and procurement specialists, understanding this compound and how to source it effectively is key to successful drug development. If you need to buy this essential intermediate, this guide provides insights into its importance and sourcing.

The Chemical Profile of 1-Fluoro-2-nitrobenzene

1-Fluoro-2-nitrobenzene is characterized by its chemical formula C6H4FNO2 and CAS number 1493-27-2. Typically appearing as a slight yellow liquid, its significance lies in its dual functionality: the fluorine atom and the nitro group attached to the benzene ring. These substituents impart specific electronic and steric properties that are highly valued in organic synthesis. The nitro group, in particular, is a precursor to amino groups, which are fundamental to many pharmaceutical structures. The fluorine atom can influence bioavailability, metabolic stability, and receptor binding affinity in drug molecules.

Role in Pharmaceutical Development

The primary utility of 1-Fluoro-2-nitrobenzene is as a key intermediate in the synthetic preparation of various pharmaceutical goods. It serves as a starting material or intermediate in complex reaction sequences that lead to novel drug candidates and established APIs. Its presence in synthesis pathways can:

  • Facilitate the introduction of nitrogen-containing functional groups.
  • Allow for the creation of fluorinated aromatic systems, which are common in modern pharmaceuticals.
  • Be modified through reduction of the nitro group, enabling further chemical elaboration.

For drug discovery and development programs, having a reliable source for high-purity 1-Fluoro-2-nitrobenzene is critical. This ensures the integrity of research data and the quality of potential drug substances.

Procurement Strategies for Pharmaceutical Companies

When seeking to purchase 1-Fluoro-2-nitrobenzene for pharmaceutical development, several factors should guide your selection of a supplier:

  • Quality Assurance: Prioritize suppliers who offer high-purity material (≥99.5%) and can provide detailed Certificates of Analysis (CoA).
  • Manufacturing Expertise: Partner with manufacturers who specialize in fine chemicals and have a proven track record in producing intermediates for the pharmaceutical industry.
  • Cost-Effectiveness: While quality is paramount, competitive pricing from reliable suppliers in China can significantly impact R&D budgets.
  • Supply Chain Reliability: Ensure the supplier can meet your volume requirements and delivery timelines consistently.

By carefully selecting a qualified manufacturer or supplier, pharmaceutical companies can secure a vital intermediate like 1-Fluoro-2-nitrobenzene, accelerating their development pipelines and bringing new therapies to market more efficiently.